Nucleotide sequence of the 3′ exon of the human N-myc gene Journal Article

   


Authors: Michitsch, R. W.; Melera, P. W.
Article Title: Nucleotide sequence of the 3′ exon of the human N-myc gene
Abstract: We have analyzed a 3.8 kb Eco RI fragment of genonric DNA obtained from the amplified N-myc gene of human neuroblastoma cell line BE(2)-C. This fragment contains an exon with an open reading frame encoding approximately 170 amino acids of the carboxy-terminal end of the putative N-myc protein. Comparison of the inferred amino acid sequence of this peptide with that of the 3′ domain of the human c-myc protein shows that locally conserved but dispersed regions of homology exist throughout the lengths of these peptides, while hydropathy plots indicate that the physical properties implied by their primary sequences are strikingly similar. Based upon these and other considerations, it is sugggested that the 3′ domains of c-myc and N-myc may potentially share related functions. © 1985 IRL Press Limited.
Keywords: genetics; comparative study; metabolism; neoplasm proteins; cell line; oncogenes; oncogene; computer; computers; amino acid sequence; neuroblastoma; nucleotide sequence; tumor protein; restriction endonuclease; base sequence; type ii site specific deoxyribonuclease; human; article; dna restriction enzymes; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; deoxyribonuclease ecori
Journal Title: Nucleic Acids Research
Volume: 13
Issue: 7
ISSN: 0305-1048
Publisher: Oxford University Press  
Date Published: 1985-04-11
Start Page: 2545
End Page: 2558
Language: English
DOI: 10.1093/nar/13.7.2545
PROVIDER: scopus
PMCID: PMC341174
PUBMED: 2987858
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022423280&doi=10.1093%2fnar%2f13.7.2545&partnerID=40&md5=1de293a2ab09b72c85924639c0f3e2ed
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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