Early clonality and high-frequency proviral integration into the c-myc locus in AKR leukemias Journal Article
| Authors: | O'Donnell, P. V.; Fleissner, E.; Lonial, H.; Koehne, C. F.; Reicin, A. |
| Article Title: | Early clonality and high-frequency proviral integration into the c-myc locus in AKR leukemias |
| Abstract: | Blot hybridization of thymocyte DNA from AKR/J mice was used to detect new proviral junction fragments as markers of clonality at different stages of viral leukemogenesis and to detect DNA rearrangements at the c-myc locus due to proviral insertion. Clonal populations of thymocytes were observed in mink cell focus-forming virus-injected mice as early as 35 days postinjection, at a stage distinguishable from frank leukemia by flow cytometric analysis and transplantation bioassay. Specific proviral integrations in the c-myc locus were deteced in 15% of these early clones and in up to 65% of late-developing thymomas and frank leukemias. Thus, in this system c-myc activation appears to be a common mechanism in T-cell leukemogenesis. - |
| Keywords: | leukemia; nonhuman; mouse; heredity; animal experiment; oncogene; gene activation; thymus; radioisotope; thymocyte; retrovirus; clone; experimental infection; murine leukemia virus; priority journal; provirus; restriction fragment |
| Journal Title: | Journal of Virology |
| Volume: | 55 |
| Issue: | 2 |
| ISSN: | 0022-538X |
| Publisher: | American Society for Microbiology |
| Date Published: | 1985-08-01 |
| Start Page: | 500 |
| End Page: | 503 |
| Language: | English |
| DOI: | 10.1128/jvi.55.2.500-503.1985 |
| PROVIDER: | scopus |
| PMCID: | PMC254961 |
| PUBMED: | 2991574 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
