Monitoring intravesical bacillus Calmette-Guerin treatment of bladder carcinoma with flow cytometry Journal Article
| Authors: | Staiano-Coico, L.; Huffman, J.; Wolf, R.; Pinsky, C. M.; Herr, H. W.; Whitmore, W. F. Jr; Oettgen, H. F.; Darzynkiewicz, Z.; Melamed, M. R. |
| Article Title: | Monitoring intravesical bacillus Calmette-Guerin treatment of bladder carcinoma with flow cytometry |
| Abstract: | Flow cytometry of bladder irrigation specimens was studied in 22 patients with low stage bladder carcinoma who were treated by transurethral resection of visible tumor followed in 3 to 5 weeks by a course of intravesical bacillus Calmette-Guerin. The most informative examinations were just before the first bacillus Calmette-Guerin treatment, 6 weeks after completing a 6-week course of treatment (3 months) and at 9 months. Of the patients 10 had recurrent tumors after therapy; recurrence was anticipated correctly by flow cytometry at the 12-week followup examination in 6 of the 10 patients and suspected in another. Of 12 patients who remained clinically free of disease for a minimum of 15 months after bacillus Calmette-Guerin therapy flow cytometry identified correctly 7 at 12 weeks, while 1 had a partial response and the remaining 4 reverted to a negative status at 9 months. Of interest, only 4 of the 22 patients were free of disease by flow cytometry at the start of bacillus Calmette-Guerin treatment despite attempted ablation of the tumor by transurethral resection, suggesting that intravesical administration of bacillus Calmette-Guerin destroys existing carcinoma in situ in some cases. |
| Keywords: | clinical article; flow cytometry; monitoring; histology; carcinoma in situ; diagnosis; transurethral resection; bladder carcinoma; therapy; bladder; prevention; bcg vaccination; male genital system; human; priority journal; bladder irrigation |
| Journal Title: | Journal of Urology |
| Volume: | 133 |
| Issue: | 5 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1985-05-01 |
| Start Page: | 786 |
| End Page: | 788 |
| Language: | English |
| DOI: | 10.1016/s0022-5347(17)49227-5 |
| PROVIDER: | scopus |
| PUBMED: | 3989917 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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