Vinblastine and methotrexate for advanced bladder cancer Journal Article
| Authors: | Ahmed, T.; Yagoda, A.; Needles, B.; Scher, H. I.; Watson, R. C.; Geller, N. |
| Article Title: | Vinblastine and methotrexate for advanced bladder cancer |
| Abstract: | Fifty-seven patients with advanced measurable urothelial tract cancer, 52 of whom had an adequate trial, were treated weekly with 3 to 4 mg. per m.2 vinblastine and 30 to 40 mg. per m.2 methotrexate. Of 3 patients with unidimensional parameters 2 showed improvement lasting 16 and 27 months, which was documented by serial cystoscopic examinations. An additional 2 patients had measurable disease that could have been encompassed in a preoperative radiotherapy field. Both patients are free of disease at more than 12 and 14 months, respectively. Of the 47 patients with bidimensionally measurable parameters 19 (40 per cent) achieved a complete or partial remission lasting a median of 8 months, with a range of 1 to 24 months. Of 25 patients with intra-abdominal or pelvic disease 7 achieved a complete or partial remission and 5 also had a minor remission. Of note, 18 of 38 patients who had received no prior chemotherapy achieved a remission versus 1 of 9 who had been treated previously (p equals 0.06). Responders frequently obtained another remission with subsequent chemotherapy (4 of 9 versus 0 of 16, p equals 0.03). Responders lived 14 months versus 8 months for nonresponders (p equals 0.02). Four responders had brain metastases compared to none of 28 nonresponders. The combination of vinblastine and methotrexate is a well tolerated, effective outpatient regimen for patients with urothelial tract cancers. |
| Keywords: | cancer chemotherapy; clinical article; cancer combination chemotherapy; diarrhea; drug efficacy; skin toxicity; methotrexate; neurotoxicity; liver toxicity; sensory neuropathy; mucosa inflammation; nausea; vomiting; bladder cancer; vinblastine; central nervous system; rash; gastrointestinal toxicity; glucose; drug therapy; alopecia; adverse drug reaction; therapy; intravenous drug administration; peripheral nervous system; bladder; nervous system; female genital system; central nervous system metastasis; bone marrow depression; preoperative radiotherapy; intoxication; bicarbonate; vaginitis; human; priority journal; blood and hemopoietic system |
| Journal Title: | Journal of Urology |
| Volume: | 133 |
| Issue: | 4 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1985-04-01 |
| Start Page: | 602 |
| End Page: | 604 |
| Language: | English |
| DOI: | 10.1016/s0022-5347(17)49106-3 |
| PROVIDER: | scopus |
| PUBMED: | 3981708 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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1130Scher -
65Geller -
51Yagoda -
25Caird Watson
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