Possible differential diagnosis of neuroblastoma from rhabdomyosarcoma and Ewing's sarcoma by using a panel of monoclonal antibodies Journal Article
| Authors: | Sugimoto, T.; Sawada, T.; Arakawa, S.; Matsumura, T.; Sakamoto, I.; Takeuchi, Y.; Reynolds, C. P.; Kemshead, J. T.; Helson, L. |
| Article Title: | Possible differential diagnosis of neuroblastoma from rhabdomyosarcoma and Ewing's sarcoma by using a panel of monoclonal antibodies |
| Abstract: | The accurate diagnosis of malignant tumor type is essential to enable the correct therapeutic regimen to be followed and to predict a patient's prognosis. However, the differential diagnosis of gsmall-round-cell htumors, represented by neuroblas toma,rhabdomyosarcoma, lymphoma/leukemia and Ewing's sarcoma, can occa sionallybe difficult by conventional morphological and biochemical methods. If tumor membrane markers were available, these could provide rapid and accurate diagnostic aids. In the present work, a panel of 9 monoclonal antibodies raised against hematopoietic cells (BA-1, BA-2, J-5 and B7/21), brain cells (UJ-13A, UJ-127-11 and anti-Thy-1), and neuroblastoma cells (HSAN1.2 and PI153/3) was used to analyze the membrane phenotypes of 12 neuroblastoma, 4 rhabdomyosarcoma and 3 Ewing's sarcoma cell lines and cells of 3 fresh bone marrow tumors. BA-1, UJ-127-11 and PI153/3 antibodies may be useful for the differential diagnosis of neuroblastoma from rhabdomyosarcoma and Ewing's sarco. © 1985, The Japanese Cancer Association. All rights reserved. |
| Keywords: | child, preschool; human cell; phenotype; bone marrow; diagnosis, differential; differential diagnosis; cell line; cancer cell culture; histology; monoclonal antibody; ewing sarcoma; antibodies, monoclonal; infant; neuroblastoma; diagnosis; bone; rhabdomyosarcoma; sarcoma, ewing's; nervous system; ewing's sarcoma; autonomic nervous system; humans; human; male; female; priority journal; cell surface membrane antigen |
| Journal Title: | Japanese Journal of Cancer Research |
| Volume: | 76 |
| Issue: | 4 |
| ISSN: | 0910-5050 |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| Date Published: | 1985-04-01 |
| Start Page: | 301 |
| End Page: | 307 |
| Language: | English |
| PUBMED: | 3924704 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
