Postoperative vaginal radiation in endometrial cancer using a remote afterloading technique Journal Article


Authors: Mandell, L.; Nori, D.; Anderson, L.; Hilaris, B.
Article Title: Postoperative vaginal radiation in endometrial cancer using a remote afterloading technique
Abstract: Carcinoma of the endometrium is the most common malignancy of the female genital tract. In early stage endometrial cancer, surgery remains the primary mode of treatment while radiation therapy plays an adjuvant role. Prophylactic vaginal radiation has been shown to reduce significantly the incidence of vaginal recurrences. Between the years 1969-1976, 330 patients with FIGO Stages I and 11 endometrial cancer were treated according to a standard departmental policy in which 40 Gy of external radiation was given to high risk Stage I and all Stage II patients in combination with surgery and intravaginal radiation. Stage I was considered high risk if the tumor was of high grade or exhibited deep myometrial invasion. Vault radiation was delivered with a remote afterloading technique to a point .5 cm from the surface of the applicator; a total dose of 21 Gy was delivered in three fractions spaced two weeks apart over four elapsed weeks. With this regimen, the mucosal surface received a total equivalent dose of 40 Gy. These treatments were given on an outpatient basis without the need for any sedation or analgesics. All patients, regardless of stage, grade, or depth of myometrial invasion received adjuvant post-operative vaginal radiation. The minimum follow-up was 5 years, with a median followup of 8.5 years. The overall pelvic and/or vaginal recurrence rate was 2.7%. The incidence of vaginal complications was 3.7%. It appears that the remote afterloading treatment (RAT) for vaginal radiation is a very cost-effective therapeutic alternative, which produces minimal early or late complications and gives complete protection from radiation exposure to the medical staff. The advantages of a remote afterloading technique in delivering vaginal vault radiation in endometrial cancer are discussed in this paper. © 1985.
Keywords: major clinical study; combined modality therapy; methodology; endometrial cancer; endometrium carcinoma; hysterectomy; vagina; brachytherapy; radioisotope; cobalt radioisotopes; uterine neoplasms; cobalt 60; therapy; vaginal neoplasms; female genital system; human; female; priority journal; remote afterloading technique; vaginal radiation
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 11
Issue: 3
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 1985-03-01
Start Page: 473
End Page: 478
Language: English
DOI: 10.1016/0360-3016(85)90177-4
PUBMED: 3972659
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Basil B Hilaris
    43 Hilaris
  2. Dattatreyudu Nori
    38 Nori
  3. Lynda R. Mandell
    24 Mandell