Adenocarcinoma of unknown primary origin: Treatment with vindesine and doxorubicin Journal Article
| Authors: | Fiore, J. J.; Kelsen, D. P.; Gralla, R. J.; Casper, E. S.; Magill, G.; Cheng, E.; Ochoa, M. Jr |
| Article Title: | Adenocarcinoma of unknown primary origin: Treatment with vindesine and doxorubicin |
| Abstract: | Adenocarcinoma of unknown primary origin (ACUP) is a common oncologic problem for which there is no standard therapy. Forty-two patients with metastatic tumor were identified as having ACUP after extensive evaluation failed to reveal a primary site of disease. They were treated with an investigational chemotherapy regimen consisting of vindesine and doxorubicin. Of the 38 evaluable patients, six (16%) had major responses to chemotherapy. The median duration of response was 4 months. The median survival of the responding patients has not been reached, but is >8 months. The median survival of the nonresponding patients was 6 months. Vindesine and doxorubin were well tolerated. The major toxicity was leukopenia, with a median wbc count nadir of 2600/mm3. We conclude that the combination of vindesine and doxorubicin has some activity in ACUP, but does not improve the response rate seen with other regimens. |
| Keywords: | survival; adult; cancer chemotherapy; clinical article; aged; middle aged; prednisone; doxorubicin; fluorouracil; cancer combination chemotherapy; drug efficacy; skin toxicity; methotrexate; neurotoxicity; adenocarcinoma; metastasis; leukopenia; nausea; neuropathy; thrombocytopenia; vomiting; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; vinblastine; gastrointestinal toxicity; cardiotoxicity; vindesine; drug therapy; toxicity; alopecia; heart; adverse drug reaction; therapy; intravenous drug administration; nervous system; bone marrow depression; intoxication; heart muscle contractility; humans; human; male; female; priority journal; blood and hemopoietic system |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 69 |
| Issue: | 6 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1985-06-01 |
| Start Page: | 591 |
| End Page: | 594 |
| Language: | English |
| PUBMED: | 4016765 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
