| Abstract: |
AKR/J (hereafter called AK) mice treated by total-body Irradiation plus syngeneic marrow transplantation developed a leukemia-lymphoma complex and concomitantly showed increased levels of lipid-bound sialic acid as was also seen in untreated AK mice between 6 weeks and 6 and 11.5 months of age. C57BL/6J (hereafter called B6) mice did not show a leukemia-lymphoma complex and did not develop elevated levels of lipid-bound sialic acid with aging. B6→AK chimeras, prepared with B6 bone marrow deprived of Thy-1.2-positive cells prior to allogeneic transplantation and kept in laminar flow isolation, did not develop graft-versus-host reactions, lived long lives (observations carried up to 13 months), failed to develop leukemia-lymphoma, and had persistently low levels of lipid-bound sialic acid. These findings indicate that introduction of resistance by marrow transplantation can inhibit development of retrovirus-induced cancer and also prevents an increase in levels of a putative cancer indicator. © 1985, American Association for Cancer Research. All rights reserved. |
| Keywords: |
leukemia; transplantation, homologous; nonhuman; animal cell; mouse; phenotype; animal; mice; heredity; animal experiment; mice, inbred c57bl; carcinogenesis; chimera; lymphatic system; lymphoma; lipids; bone marrow transplantation; therapy; retrovirus; sialic acids; reticuloendothelial system; sialic acid; male; priority journal; leukemia, experimental; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; mice, inbred akr; blood and hemopoietic system
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