Stimulation of Rauscher leukemia virus DNA polymerase DNA-directed DNA synthesis by cationic trypanocides and polyamines Journal Article
| Authors: | Marcus, S. L.; Petrylak, D. P.; Burchenal, J. J.; Bacchi, C. J. |
| Article Title: | Stimulation of Rauscher leukemia virus DNA polymerase DNA-directed DNA synthesis by cationic trypanocides and polyamines |
| Abstract: | Activated DNA-directed DNA synthesis catalyzed by Rauscher leukemia virus (RLV) and other type C mammalian retroviral DNA polymerases is uniquely stimulated by biologically active polyamines. Cationic trypanocides may act as antagonists of polyamine function. As described here, several cationic trypanocides stimulate RLV polymerase-catalyzed DNA-directed DNA synthesis at concentrations significantly inhibiting eukaryotic DNA polymerases. Such stimulation is negated by polyamines. Kinetic analysis of the stimulation of RLV DNA polymerase by three structurally dissimilar cationic trypanocides (Antrycide, Burroughs-Wellcome Compound 64A, and Bayer Compound 1694) suggests that such stimulation is, in part, due to a drug:DNA structural interaction resembling the polyamine:DNA structural complex recognized by the RLV DNA polymerase. © 1985, American Association for Cancer Research. All rights reserved. |
| Keywords: | nonhuman; comparative study; dna polymerase; dna replication; structure-activity relationship; kinetics; dna-directed dna polymerase; polyamine; polyamines; cations; priority journal; support, u.s. gov't, p.h.s.; rauscher leukemia virus; rauscher virus; antitrypanosomal agent; trypanocidal agents |
| Journal Title: | Cancer Research |
| Volume: | 45 |
| Issue: | 1 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1985-01-01 |
| Start Page: | 112 |
| End Page: | 115 |
| Language: | English |
| PUBMED: | 3965127 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |