The graded and quantal nature of opioid analgesia in the rat tailflick assay Journal Article
| Authors: | Yoburn, B. C.; Cohen, A.; Umans, J. G.; Ling, G. S. F.; Inturrisi, C. E. |
| Article Title: | The graded and quantal nature of opioid analgesia in the rat tailflick assay |
| Abstract: | Opioid agonists routinely increase the latency to respond in the rodent tailflick assay. The nature of this effect was investigated in 5 experiments using several parametric variations and routes of administration. Morphine and methadone were found to produce both quantal and graded effects in all experiments. In cases where quantal effects were observed, the majority of animals also responded in a graded manner during subsequent testing. The increase in latency to respond in the tailflick assay produced by opioid agonists is not accurately characterized as predominantly quantal. © 1985. |
| Keywords: | placebo; drug efficacy; nonhuman; animals; pain; animal experiment; dose-response relationship, drug; central nervous system; kinetics; rat; rats; drug dose; opioids; methadone; morphine; analgesia; nociception; tail flick test; drug interaction; reaction time; male; priority journal; tailflick assay; graded response; quantal response |
| Journal Title: | Brain Research |
| Volume: | 331 |
| Issue: | 2 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1985-04-08 |
| Start Page: | 327 |
| End Page: | 336 |
| Language: | English |
| DOI: | 10.1016/0006-8993(85)91558-6 |
| PUBMED: | 3986573 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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