Authors: | Rottenberg, D. A.; Ginos, J. Z.; Kearfott, K. G.; Junck, L.; Dhawan, V.; Jarden, J. O. |
Article Title: | In vivo measurement of brain tumor pH using [(11)C]DMO and positron emission tomography |
Abstract: | In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using[11C]dimethyloxazolidinedione ([11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter. Copyright © 1985 the American Neurological Association |
Keywords: | adult; clinical article; middle aged; unclassified drug; positron emission tomography; brain tumor; brain neoplasms; ph; central nervous system; drug accumulation; diagnosis; radioisotope; hydrogen-ion concentration; white matter; tomography, emission-computed; gray matter; oxazoles; carbon radioisotopes; humans; human; male; female; priority journal; article; dimethadione c 11; dimethadione |
Journal Title: | Annals of Neurology |
Volume: | 17 |
Issue: | 1 |
ISSN: | 0364-5134 |
Publisher: | Wiley Blackwell |
Date Published: | 1985-01-01 |
Start Page: | 70 |
End Page: | 79 |
Language: | English |
DOI: | 10.1002/ana.410170116 |
PUBMED: | 3872621 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |