In vivo measurement of brain tumor pH using [(11)C]DMO and positron emission tomography Journal Article


Authors: Rottenberg, D. A.; Ginos, J. Z.; Kearfott, K. G.; Junck, L.; Dhawan, V.; Jarden, J. O.
Article Title: In vivo measurement of brain tumor pH using [(11)C]DMO and positron emission tomography
Abstract: In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using[11C]dimethyloxazolidinedione ([11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter. Copyright © 1985 the American Neurological Association
Keywords: adult; clinical article; middle aged; unclassified drug; positron emission tomography; brain tumor; brain neoplasms; ph; central nervous system; drug accumulation; diagnosis; radioisotope; hydrogen-ion concentration; white matter; tomography, emission-computed; gray matter; oxazoles; carbon radioisotopes; humans; human; male; female; priority journal; article; dimethadione c 11; dimethadione
Journal Title: Annals of Neurology
Volume: 17
Issue: 1
ISSN: 0364-5134
Publisher: Wiley Blackwell  
Date Published: 1985-01-01
Start Page: 70
End Page: 79
Language: English
DOI: 10.1002/ana.410170116
PUBMED: 3872621
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Vijay Dhawan
    22 Dhawan
  2. James Z. Ginos
    15 Ginos