The nude mouse in cancer research Journal Article
| Authors: | Giovanella, B. C.; Fogh, J. |
| Article Title: | The nude mouse in cancer research |
| Abstract: | The nude mouse is considered a marvel as a laboratory animal and in many respects is uniquely qualified for in vivo model studies of human cancer. Most human tumors have been transplanted to nude mice and tumor lines are established with varying degrees of ease. It is noted that the additional immunosuppression of the mice or the use of very young animals can increase tumor growth and malignant expression. Other variables that affect tumor transplantation include the health of the mice, site of injection of the transplant, and specific properties or requirements of the human tumor cells. Hormone-dependent human tumors are grown in nude mice, either in special sites or after hormonal supplement. It is observed that the tumor growth rates differ in nude mice and in cancer patient and this tumor heterogeneity occasionally result in the growth of selected tumor components. These differences do not necessarily demean the human tumor-nude mouse model, but is well in line with the changes occurring with time in the human patient tumors. Many tumor characteristics appear to be stable in the nude mouse, and it has been shown that tumor markers and secretion of certain hormones may be maintained in the xenografts. © 1985, Elsevier Inc. All rights reserved. |
| Keywords: | review; methodology; neoplasm; neoplasms; mouse; animal; mice; cells, cultured; cell division; metastasis; drug screening; pathology; drug evaluation, preclinical; cell transformation, neoplastic; monoclonal antibody; antibodies, monoclonal; species specificity; xenograft; cell culture; nude mouse; mice, nude; cell transformation; research; neoplasm metastasis; transplantation, heterologous; species difference; sex difference; neoplasm transplantation; sex factors; cancer transplantation; nutrition; human; male; female |
| Journal Title: | Advances in Cancer Research |
| Volume: | 44 |
| ISSN: | 0065-230X |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 1985-01-01 |
| Start Page: | 69 |
| End Page: | 120 |
| Language: | English |
| DOI: | 10.1016/s0065-230x(08)60026-3 |
| PUBMED: | 3898740 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 26 October 2021 -- Source: Scopus |
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