Hürthle cell carcinoma of the thyroid gland: Systematic review and meta-analysis Review
| Authors: | Coca-Pelaz, A.; Rodrigo, J. P.; Shah, J. P.; Sanabria, A.; Al Ghuzlan, A.; Silver, C. E.; Shaha, A. R.; Angelos, P.; Hartl, D. M.; Mäkitie, A. A.; Olsen, K. D.; Owen, R. P.; Randolph, G. W.; Simó, R.; Tufano, R. P.; Kowalski, L. P.; Zafereo, M. E.; Rinaldo, A.; Ferlito, A. |
| Review Title: | Hürthle cell carcinoma of the thyroid gland: Systematic review and meta-analysis |
| Abstract: | Introduction: Hürthle cell carcinoma (HCC) comprises about 5% of thyroid carcinoma cases. Partly because of its rarity there is much we still need to know about HCC as compared to other histological cancer subtypes. Methods: We conducted a systematic literature review following PRISMA guidelines and meta-analysis, from 2000 to 2020, to investigate the main characteristics of HCC and clarify information concerning tumor behavior and treatment. Results: Our review included data from 9638 patients reported in 27 articles over the past 20 years. This tumor occurred more frequently in women (67.5%). The mean age was 57.6 years, and the mean size of the neoplasm at diagnosis was 30 mm. Extrathyroidal extension was common (24%) but lymph node metastasis was not (9%). Total thyroidectomy was the most common surgical approach, with neck dissection usually performed in cases with clinically apparent positive neck nodes. Radioiodine therapy was frequently applied (54%), although there is no consensus about its benefits. The mean 5- and 10-year overall survival was 91% and 76%, respectively. Conclusion: This review serves to further elucidate the main characteristics of this malignancy. HCC of the thyroid is rare and most often presents with a relatively large nodule, whereas lymph node metastases are rare. Given the rarity of HCC, a consensus on their treatment is needed, as doubts remain concerning the role of specific tumor findings and their influence on management. © 2021, The Author(s), under exclusive licence to Springer Healthcare Ltd., part of Springer Nature. |
| Keywords: | lymph node metastasis; thyroid; tumor size; radioiodine therapy; hürthle cell carcinoma |
| Journal Title: | Advances in Therapy |
| Volume: | 38 |
| Issue: | 10 |
| ISSN: | 0741-238X |
| Publisher: | Springer |
| Date Published: | 2021-10-01 |
| Start Page: | 5144 |
| End Page: | 5164 |
| Language: | English |
| DOI: | 10.1007/s12325-021-01876-7 |
| PROVIDER: | scopus |
| PUBMED: | 34423400 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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