Safe harbours for the integration of new DNA in the human genome Journal Article
| Authors: | Sadelain, M.; Papapetrou, E. P.; Bushman, F. D. |
| Article Title: | Safe harbours for the integration of new DNA in the human genome |
| Abstract: | DNA and the host genome limit the reliability and safety of transgene integration for therapeutic cell engineering and other applications. Although targeted gene delivery has made considerable progress, the question of where to insert foreign sequences in the human genome to maximize safety and efficacy has received little attention. In this Opinion article, we discuss 'genomic safe harbours'-chromosomal locations where therapeutic transgenes can integrate and function in a predictable manner without perturbing endogenous gene activity and promoting cancer. © 2012 Macmillan Publishers Limited. All rights reserved. |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-01-01 |
| Start Page: | 51 |
| End Page: | 58 |
| Language: | English |
| DOI: | 10.1038/nrc3179 |
| PROVIDER: | scopus |
| PUBMED: | 22129804 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2012" - "CODEN: NRCAC" - "Source: Scopus" |
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