Emerging treatments and aignaling pathway inhibitors Journal Article
| Authors: | Tang, J. Y.; Marghoob, A. A. |
| Article Title: | Emerging treatments and aignaling pathway inhibitors |
| Abstract: | A number of therapies that target components of the Hedgehog signaling pathway currently are in clinical trials. The specific molecules that seem most promising in basal cell carcinoma and a number of other cancers are those that target the Smoothened transmembrane protein. The pivotal phase II trials have been completed on the Smoothened inhibitor known as GDC-0449; five other agents (BMS-833923, LDE225, LEQ506, IPI926, and TAK-441) have also shown promise in animal studies and early clinical trials and have shown some efficacy in a variety of cancers that are affected by the Hedgehog signaling pathway. © 2011 Elsevier Inc. |
| Keywords: | signal transduction; gene mutation; disease course; squamous cell carcinoma; fluorouracil; nonhuman; antineoplastic agents; pyridines; treatment; ultraviolet radiation; gene targeting; imiquimod; basal cell carcinoma; skin neoplasms; sonic hedgehog protein; hedgehog proteins; tumor suppressor gene; neuroblastoma; medulloblastoma; cyclopamine; rhabdomyosarcoma; photodynamic therapy; photochemotherapy; astrocytoma; carcinoma, basal cell; xeroderma pigmentosum; secondary prevention; anilides; toll like receptor; retinoid; basal cell nevus syndrome; viral proteins; aminolevulinic acid; retinoids; aminoquinolines; hedgehog; vismodegib; deoxyribonuclease (pyrimidine dimer); hedgehog signaling pathway; smoothened inhibitors; erismodegib; hepatoblastoma |
| Journal Title: | Seminars in Cutaneous Medicine and Surgery |
| Volume: | 30 |
| Issue: | 4 Suppl. |
| ISSN: | 1085-5629 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | S14 |
| End Page: | S18 |
| Language: | English |
| DOI: | 10.1016/j.sder.2011.11.002 |
| PROVIDER: | scopus |
| PUBMED: | 22177102 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2012" - "CODEN: SCMSF" - "Source: Scopus" |
