Counting mitoses: SI(ze) matters! Journal Article


Authors: Cree, I. A.; Tan, P. H.; Travis, W. D.; Wesseling, P.; Yagi, Y.; White, V. A.; Lokuhetty, D.; Scolyer, R. A.
Article Title: Counting mitoses: SI(ze) matters!
Abstract: Mitoses are often assessed by pathologists to assist the diagnosis of cancer, and to grade malignancy, informing prognosis. Historically, this has been done by expressing the number of mitoses per n high power fields (HPFs), ignoring the fact that microscope fields may differ substantially, even at the same high power (×400) magnification. Despite a requirement to define HPF size in scientific papers, many authors fail to address this issue adequately. The problem is compounded by the switch to digital pathology systems, where ×400 equivalent fields are rectangular and also vary in the area displayed. The potential for error is considerable, and at times this may affect patient care. This is easily solved by the use of standardized international (SI) units. We, therefore, recommend that features such as mitoses are always counted per mm2, with an indication of the area to be counted and the method used (usually “hotspot” or “average”) to obtain the results. © 2021, World Health Organization.
Keywords: adult; review; mitosis; patient care; human; international standard unit
Journal Title: Modern Pathology
Volume: 34
Issue: 9
ISSN: 0893-3952
Publisher: Nature Research  
Date Published: 2021-09-01
Start Page: 1651
End Page: 1657
Language: English
DOI: 10.1038/s41379-021-00825-7
PUBMED: 34079071
PROVIDER: scopus
PMCID: PMC8376633
DOI/URL:
Notes: Review -- Export Date: 1 October 2021 -- Source: Scopus
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  1. William D Travis
    743 Travis
  2. Yukako Yagi
    74 Yagi