Predictive value of preoperative neutrophil-to-lymphocyte ratio in localized prostate cancer: Results from a surgical series at a high-volume institution Journal Article
| Authors: | Bravi, C. A.; Rosiello, G.; Fallara, G.; Vertosick, E.; Tin, A.; Sjoberg, D.; Bianchi, M.; Mazzone, E.; Martini, A.; Dell'Oglio, P.; Stabile, A.; Gandaglia, G.; Fossati, N.; Briganti, A.; Montorsi, F.; Vickers, A. |
| Article Title: | Predictive value of preoperative neutrophil-to-lymphocyte ratio in localized prostate cancer: Results from a surgical series at a high-volume institution |
| Abstract: | BACKGROUND: To examine the predictive value of neutrophil-to-lymphocyte ratio in localized prostate cancer for surgical pathology and recurrence in patients treated by radical prostatectomy METHODS: We evaluated 1258 patients treated by radical prostatectomy at San Raffaele Hospital between 2011 and 2017 and assessed the association between preoperative neutrophil-to-lymphocyte ratio and surgical pathology (advanced stage, grade group ≥4, nodal involvement, grade discordance between biopsy and surgical pathology) and biochemical recurrence. RESULTS: The preoperative neutrophil-to-lymphocyte ratio was not significantly associated with advanced stage (≥T3), International Society of Urological Pathology (ISUP) grade (≥4) or discordance. At multivariable analysis, patients with higher neutrophil-to-lymphocyte ratio had lower risk of nodal involvement at final pathology (odds ratio [OR]: 0.77; 95% confidence interval [CI]: 0.64, 0.92; P=0.005). The preoperative level of neutrophil-to-lymphocyte ratio was associated with biochemical recurrence on univariate analysis (OR: 0.81, 95% CI: 0.68, 0.96; P=0.017). Such a relationship was not significant at multivariable analysis adjusting for tumor severity (OR: 0.93, 95% CI: 0.79, 1.09; P=0.4). CONCLUSIONS: Neutrophil-to-lymphocyte ratio does not have clinical utility for the prediction of adverse pathology and biochemical recurrence. Further research should focus on its value for predicting regional lymph node metastasis. © 2020 Tehran University of Medical Sciences. All rights reserved. |
| Keywords: | prostatic neoplasms; prostatectomy; neoplasm metastasis |
| Journal Title: | Minerva Urology and Nephrology |
| Volume: | 73 |
| Issue: | 4 |
| ISSN: | 2724-6051 |
| Publisher: | Edizioni Minerva Medica |
| Date Published: | 2021-08-01 |
| Start Page: | 481 |
| End Page: | 488 |
| Language: | English |
| DOI: | 10.23736/s2724-6051.20.03662-0 |
| PROVIDER: | scopus |
| PUBMED: | 32083416 |
| PMCID: | PMC9514026 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 October 2021 -- Source: Scopus |
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