Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib Journal Article
| Authors: | Molina, A. M.; Ginsberg, M. S.; Motzer, R. J. |
| Article Title: | Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib |
| Abstract: | A 70-year-old man with metastatic renal cell carcinoma developed progressive liver metastases after 8 weeks of treatment with the multitargeted tyrosine kinase inhibitor (TKI) sunitinib. He then participated in the phase III placebo-controlled clinical trial of the oral mammalian target of rapamycin (mTOR) inhibitor everolimus, initially randomized to placebo (but had disease progression after 3 months) and crossed over to everolimus at time of unblinding. The patient had stable disease after 8 weeks (two cycles) of everolimus that was maintained until 28 months of therapy, at which time the patient had achieved a partial response. This case illustrates the potential for patients with metastatic renal cell carcinoma, a malignancy with historically poor prognosis, to derive long-term benefit from everolimus when used in a manner consistent with its approved indication (after TKI therapy with sunitinib or sorafenib). © 2010 Springer Science+Business Media, LLC. |
| Keywords: | human tissue; treatment response; aged; fatigue; anamnesis; cancer recurrence; case report; salvage therapy; placebo; sunitinib; cancer growth; drug withdrawal; hypertension; antineoplastic agents; metastasis; computer assisted tomography; multiple cycle treatment; stomatitis; lung neoplasms; randomized controlled trials as topic; renal cell carcinoma; kidney carcinoma; kidney neoplasms; nephrectomy; rash; liver metastasis; cancer regression; karnofsky performance status; carcinoma, renal cell; clinical trials, phase iii as topic; hypercholesterolemia; kidney cancer; indoles; pyrroles; alcohol consumption; everolimus; sirolimus; hypertriglyceridemia; mtor; metastatic; hypertransaminasemia; metastasis resection; arthritis, rheumatoid; ankle edema |
| Journal Title: | Medical Oncology |
| Volume: | 28 |
| Issue: | 4 |
| ISSN: | 1357-0560 |
| Publisher: | Humana Press Inc |
| Date Published: | 2011-01-01 |
| Start Page: | 1527 |
| End Page: | 1529 |
| Language: | English |
| DOI: | 10.1007/s12032-010-9640-y |
| PROVIDER: | scopus |
| PMCID: | PMC3219862 |
| PUBMED: | 20697842 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2012" - "CODEN: MONCE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work