Prospects for epigenetic targeted therapies of bone and soft-tissue sarcomas Review

   


Authors: Wang, J.; Elkrief, A.; Guo, W.; Shukla, N.; Gounder, M.; Ladanyi, M.
Review Title: Prospects for epigenetic targeted therapies of bone and soft-tissue sarcomas
Abstract: Targeted therapies have revolutionized cancer treatment. It is well established that alterations of chromatin configuration and modifications affect tumorigenesis of some, possibly most, bone and soft-tissue sarcomas. As epigenetic regulators play a major role in the development of bone and soft-tissue sarcomas, epigenetic drugs provide a novel potential avenue for rational targeted therapies for these aggressive cancers. The present review summarizes the application of epigenetic drugs for clinical utilization in bone and soft-tissue sarcomas and provides an overview of clinical trials currently evaluating epigenetic therapies in this space. © 2021 Jun Wang et al.
Journal Title: Sarcoma
Volume: 2021
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2021-07-26
Start Page: 5575444
Language: English
DOI: 10.1155/2021/5575444
PROVIDER: scopus
PMCID: PMC8328687
PUBMED: 34349608
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112331978&doi=10.1155%2f2021%2f5575444&partnerID=40&md5=a5ec54ce489179968e10eaba6c00ef38
Notes: Review -- Export Date: 1 September 2021 -- Source: Scopus
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MSK Authors
  1. Marc Ladanyi
    1329 Ladanyi
  2. Mrinal M Gounder
    229 Gounder
  3. Neerav Shukla
    159 Shukla
  4. Arielle Elkrief
    42 Elkrief
  5. Jun Wang
    1 Wang
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