The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the interventional management of cancer-associated pain Guidelines


Authors: Aman, M. M.; Mahmoud, A.; Deer, T.; Sayed, D.; Hagedorn, J. M.; Brogan, S. E.; Singh, V.; Gulati, A.; Strand, N.; Weisbein, J.; Goree, J. H.; Xing, F.; Valimahomed, A.; Pak, D. J.; El Helou, A.; Ghosh, P.; Shah, K.; Patel, V.; Escobar, A.; Schmidt, K.; Shah, J.; Varshney, V.; Rosenberg, W.; Narang, S.
Title: The American Society of Pain and Neuroscience (ASPN) best practices and guidelines for the interventional management of cancer-associated pain
Abstract: Moderate to severe pain occurs in many cancer patients during their clinical course and may stem from the primary pathology, metastasis, or as treatment side effects. Uncontrolled pain using conservative medical therapy can often lead to patient distress, loss of productivity, shorter life expectancy, longer hospital stays, and increase in healthcare utilization. Various publications shed light on strategies for conservative medical management for cancer pain and a few international publications have reviewed limited interventional data. Our multi-institutional working group was assembled to review and highlight the body of evidence that exists for opioid utilization for cancer pain, adjunct medication such as ketamine and methadone and interventional therapies. We discuss neurolysis via injections, neuromodulation including targeted drug delivery and spinal cord stimulation, vertebral tumor ablation and augmentation, radiotherapy and surgical techniques. In the United States, there is a significant variance in the interventional treatment of cancer pain based on fellowship training. As a first of its kind, this best practices and interventional guideline will offer evidenced-based recommendations for reducing pain and suffering associated with malignancy. © 2021 Aman et al.
Keywords: cancer surgery; treatment failure; unclassified drug; review; united states; bone metastasis; drug targeting; cancer radiotherapy; nuclear magnetic resonance imaging; evidence based practice; bisphosphonic acid derivative; cancer pain; practice guideline; neuromodulation; pethidine; medical education; tramadol; surgical infection; external beam radiotherapy; radioisotope; methadone; morphine; radiofrequency ablation; epidural analgesia; hydromorphone; analgesia; radiofrequency; fentanyl; ketamine; oxycodone; neurolysis; pharmacokinetic parameters; codeine; oxymorphone; hypogastric plexus; denosumab; tumor ablation; radium 223; spinal hematoma; samarium 153; strontium 89; celiac plexus; sympathetic blocking; human; intrathecal drug delivery; spinal cord stimulation; intrathecal drug administration; superior hypogastric plexus; ganglion impar block; pain pump; vertebral augmentation; resiniferatoxin; complex regional pain syndrome type i; complex regional pain syndrome type ii; cordotomy (spinal cord); ganglion block; intrathecal analgesia
Journal Title: Journal of Pain Research
Volume: 14
ISSN: 1178-7090
Publisher: Dove Medical Press Ltd  
Date Published: 2021-01-01
Start Page: 2139
End Page: 2164
Language: English
DOI: 10.2147/jpr.S315585
PROVIDER: scopus
PMCID: PMC8292624
PUBMED: 34295184
DOI/URL:
Notes: Review -- Export Date: 1 September 2021 -- Source: Scopus
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  1. Amitabh Gulati
    155 Gulati