Potentiation of growth factor activity by exogenous c-myc expression Journal Article
| Authors: | Sorrentino, V.; Drozdoff, V.; McKinney, M. D.; Zeitz, L.; Fleissner, E. |
| Article Title: | Potentiation of growth factor activity by exogenous c-myc expression |
| Abstract: | The c-myc oncogene has been implicated in deregulation of cell growth in neoplastic cells and response to 'competence-inducing' growth factors in normal cells. In the latter case, expression of c-myc has been shown to be associated with the transition from the G0 to the G1 phase of the cell cycle induced by platelet-derived growth factor (PDGF). In work reported here, we have introduced the c-myc coding region, in a retroviral vector, into mouse and rat cells. We show that under conditions of anchorage-independent growth, constitutive c-myc expression increases the response of rodent cells to PDGF, as well as to other growth factors of both the competence-inducing and 'progression' classes. These effects of the myc product are observed whether or not an exogenous ras gene has also been introduced into the same cells. Possible models for the influence of myc on growth responses are discussed. |
| Keywords: | epidermal growth factor; platelet derived growth factor; nonhuman; mouse; models, biological; cell line; in vitro study; cell transformation, neoplastic; rat; platelet-derived growth factor; transforming growth factors; rodentia; oncogene c myc; growth factor; anchorage independent growth; growth substances; proto-oncogenes; priority journal; peptide biosynthesis |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 83 |
| Issue: | 21 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1986-11-01 |
| Start Page: | 8167 |
| End Page: | 8171 |
| Language: | English |
| DOI: | 10.1073/pnas.83.21.8167 |
| PUBMED: | 3490663 |
| PROVIDER: | scopus |
| PMCID: | PMC386888 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
