Human lactic dehydrogenase as a marker for monitoring the growth of prostatic carcinoma in nude mice Journal Article
| Authors: | Heckl, W.; Fogh, J. |
| Article Title: | Human lactic dehydrogenase as a marker for monitoring the growth of prostatic carcinoma in nude mice |
| Abstract: | Human lactate dehydrogenase (1,1,1,27-LDH) isoenzymes were determined in human prostatic carcinoma cell lines. The isoenzymes LDH-4/LDH-5 were identified and quantified in the serum of athymic mice bearing the human prostatic carcinoma cell lines PC-3, PC-3/M and DU 145 subcutaneously. The amounts of the slowly migrating isoenzymes released by the solid tumors correlated with increasing tumor volume and tumor weight. These correlations indicate that the human LDH-4/LDH-5 isoenzymes are useful parameters for monitoring the presence and growth of prostatic cancer in the athymic animal model. © 1986 S. Karger AG, Basel. |
| Keywords: | human cell; cancer growth; nonhuman; adenocarcinoma; mouse; animal; mice; tumor volume; cell line; animal model; prostatic neoplasms; mice, nude; diagnosis; lactate dehydrogenase; disease models, animal; isoenzymes; prostate carcinoma; male genital system; tumor weight; prostatic carcinoma; human; male; female; priority journal; lactic dehydrogenase isoenzymes |
| Journal Title: | Pathobiology |
| Volume: | 54 |
| Issue: | 1 |
| ISSN: | 1015-2008 |
| Publisher: | S. Karger AG |
| Date Published: | 1986-01-01 |
| Start Page: | 34 |
| End Page: | 39 |
| Language: | English |
| DOI: | 10.1159/000163341 |
| PUBMED: | 3956838 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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