Effect of high/low dietary linoleic acid feeding on mouse splenocytes: Modulation by age and influence of genetic variability Journal Article


Authors: Tiwari, R. K.; Clandinin, M. T.; Cinader, B.
Article Title: Effect of high/low dietary linoleic acid feeding on mouse splenocytes: Modulation by age and influence of genetic variability
Abstract: Young and old mice of several strains were fed semipurified diets differing in polyunsaturated to saturated fatty acid ratio. The level of linoleic acid in phosphatidylcholine and phosphatidylethanolamine fractions of splenocyte membrane was determined. Lower levels of linoleic acid in membranes of older animals were observed when compared with membranes of young animals fed diets for the same period. Change in 18:2(6) content of splenocytes, as a result of feeding the different diets for periods of 1, 4, or 6 weeks, was observed. The degree of change in membrane 18:2(6) content was strain-dependent. These results suggest that regulatory balance for integration of fatty acyl chains into the phospholipid matrix may be age-related and genetically controlled. © 1986 Pergamon Journals Ltd.
Keywords: nonhuman; animal cell; mouse; mice; heredity; spleen; animal experiment; genetic variability; strain difference; age; cell membrane; phosphatidylethanolamine; phosphatidylcholine; spleen cell; phospholipids; phospholipid; linoleic acid; fat intake; polyunsaturated fatty acid; priority journal; inbred strains
Journal Title: Nutrition Research
Volume: 6
Issue: 12
ISSN: 0271-5317
Publisher: Elsevier Inc.  
Date Published: 1986-12-01
Start Page: 1379
End Page: 1387
Language: English
DOI: 10.1016/s0271-5317(86)80023-9
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
Altmetric
Citation Impact
MSK Authors
  1. Raj K. Tiwari
    15 Tiwari