Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration Journal Article

  


Authors: Cunningham, J.; Graus, F.; Anderson, N.; Posner, J. B.
Article Title: Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration
Abstract: Serum from seven patients with paraneoplastic cerebellar degeneration contained anti-Purkinje cell antibodies. The samples were examined by immunoblotting to determine whether they recognized common antigens in isolated human Purkinje cell neurons. Two groups of antigens were detected by all seven sera with Mr 62/64 kd and 34 to 38 kd, both of which contributed to the Purkinje cell antigens detected immunohistochemically. These reactivities were absent from all controls tested. These antibodies may play a role in the pathogenesis of paraneoplastic cerebellar degeneration. © 1986 American Academy of Neurology.
Keywords: immunohistochemistry; cytology; purkinje cell; purkinje cells; central nervous system; antigens; diagnosis; antibodies; cerebral cortex; malignant transformation; serum; antibody; cerebellar diseases; immunologic techniques; paraneoplastic syndromes; cerebellum degeneration; human; male; female; priority journal; support, non-u.s. gov't
Journal Title: Neurology
Volume: 36
Issue: 9
ISSN: 0028-3878
Publisher: Lippincott Williams & Wilkins  
Date Published: 1986-09-01
Start Page: 1163
End Page: 1168
Language: English
DOI: 10.1212/wnl.36.9.1163
PUBMED: 3528917
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022543286&doi=10.1212%2fwnl.36.9.1163&partnerID=40&md5=93149035546aa7060600cabb06eb953d
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Jerome B Posner
    211 Posner
  2. Neil E. Anderson
    15 Anderson
Related MSK Work