Estimation and prediction of cell cycle specific effects of anticancer drugs Journal Article
| Authors: | Kimmel, M.; Traganos, F. |
| Article Title: | Estimation and prediction of cell cycle specific effects of anticancer drugs |
| Abstract: | A mathematical model is used to estimate the cell cycle phase specific action of a new anticancer drug, CI-921, based on results of a short term (8 hr) stathmokinetic (blocked divisions) study on Friend leukemia cells. The estimate obtained is in the form of a sequence of fractions of the cell flow blocked in successive subcompartments of the cell cycle. At specific drug concentrations, the information contained in this estimate is sufficient to correctly predict the results of long term (24 hr) continuous drug exposure. The result obtained seems to be of interest, since the ability to predict the cell cycle phase specific effects of anticancer drugs is crucial for any attempt to improve the existing chemotherapeutic treatment schedules for cancer. This study required developing new mathematical techniques, among them a nonparametric method for estimation of the distributions of cell residence times in the G1 phase of the cell cycle (Appendix). The methods developed are general enough to be applicable, in principle, to any chemotherapeutic agent the action of which is distributed throughout the cell cycle. © 1986. |
| Keywords: | cancer chemotherapy; doxorubicin; drug efficacy; nonhuman; chemotherapy; antineoplastic agent; animal cell; animal; cell cycle; in vitro study; vinblastine; mathematical model; daunorubicin; amsacrine; therapy; drug products; topical drug administration; new drug; nonbiological model; anticancer drugs; priority journal; asulacrine isethionate; friend leukemia; blood and hemopoietic system; biochemistry - medical applications; biomedical engineering - cytology; mathematical models - medical applications; cell-cycle phase-specific action of drug; stathmokinesis (blocked cell-division) |
| Journal Title: | Mathematical Biosciences |
| Volume: | 80 |
| Issue: | 2 |
| ISSN: | 0025-5564 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1986-08-01 |
| Start Page: | 187 |
| End Page: | 208 |
| Language: | English |
| DOI: | 10.1016/0025-5564(86)90044-1 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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