Long-term endocrine sequelae after treatment of medulloblastoma: Prospective study of growth and thyroid function Journal Article
| Authors: | Oberfield, S. E.; Allen, J. C.; Pollack, J.; New, M. I.; Levine, L. S. |
| Article Title: | Long-term endocrine sequelae after treatment of medulloblastoma: Prospective study of growth and thyroid function |
| Abstract: | Endocrine evaluations were performed prospectively in 22 patients with medulloblastoma (ages 2 1/2 to 23 1/2 years at diagnosis), after craniospinal radiation with or without adjuvant chemotherapy. The mean craniospinal (hypothalamic-pituitary) and thyroid radiation doses were 3600 and 2400 rads, respectively. Fourteen (73%) of 19 patients who had not yet completed their growth experienced a decrease in growth velocity. However, only three of 10 of these children, who underwent growth hormone stimulation tests, had evidence of deficient growth hormone responses, suggesting that growth hormone secretory or regulatory dysfunction, rather than absolute growth hormone deficiency, is present in the majority of these children. Elevated thyroid-stimulating hormone levels were noted in 15 of 22 patients; one patient had hypothalamic hypothyroidism. Thus, the late effects of therapy for medulloblastoma include frequent endocrine morbidity involving hypothalamic-pituitary and thyroid dysfunction. © 1986 The C. V. Mosby Company. |
| Keywords: | adolescent; adult; cancer chemotherapy; child; clinical article; child, preschool; cancer radiotherapy; radiation dose; combined modality therapy; prospective studies; antineoplastic combined chemotherapy protocols; growth hormone; childhood cancer; central nervous system; time factors; radiation dosage; risk; growth disorders; diagnosis; medulloblastoma; spine; bone; thyroid gland; cerebellar neoplasms; therapy; thyroid function tests; thyrotropin; growth rate; endocrine system; growth; thyroid function; hypothalamo-hypophyseal system; humans; human; male; female; priority journal |
| Journal Title: | Journal of Pediatrics |
| Volume: | 108 |
| Issue: | 2 |
| ISSN: | 0022-3476 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-02-01 |
| Start Page: | 219 |
| End Page: | 223 |
| Language: | English |
| DOI: | 10.1016/s0022-3476(86)80986-6 |
| PUBMED: | 3944706 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
