Pretreatment nomogram predicting ten-year biochemical outcome of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer Journal Article
| Authors: | Zelefsky, M. J.; Kattan, M. W.; Fearn, P.; Fearon, B. L.; Stasi, J. P.; Shippy, A. M.; Scardino, P. T. |
| Article Title: | Pretreatment nomogram predicting ten-year biochemical outcome of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer |
| Abstract: | Objectives: To update our previously published nomogram predicting for biochemical outcome with 10-year data from a larger cohort of patients treated with three-dimensional conformal radiotherapy (RT) or intensity-modulated RT for localized prostate cancer. Methods: From 1988 to 2004, 2253 patients were treated with three-dimensional conformal RT or intensity-modulated RT for clinical Stage T1-T3 prostate cancer. Prescription doses ranged from 64.8 to 86.4 Gy. The median follow-up time was 7 years. The nomogram was developed using a proportional hazards regression model predicting for the probability of biochemical relapse after RT according to the nadir plus 2 ng/mL definition of prostate-specific antigen (PSA) relapse. Results: The 10-year PSA relapse-free survival rate was 62%. The nomogram incorporated the following variables to predict likelihood of PSA failure after RT: pretreatment PSA level, Gleason score, radiation dose, use of neoadjuvant androgen deprivation, and clinical stage. The concordance index of this long-term nomogram was 0.72. Conclusions: A nomogram predicting the 10-year probability of biochemical control after three-dimensional conformal RT or intensity-modulated RT for prostate cancer was reasonably accurate and discriminating. The nomogram also provided evidence that long-term biochemical control can be achieved after conformal RT for the treatment of localized prostate cancer. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | adult; cancer survival; treatment outcome; aged; aged, 80 and over; middle aged; major clinical study; androgen; intensity modulated radiation therapy; cancer radiotherapy; radiation dose; cancer staging; follow up; follow-up studies; prostate specific antigen; radiotherapy dosage; prediction; time factors; prostate cancer; gleason score; prostate-specific antigen; prostatic neoplasms; nomograms; radiotherapy, conformal; computer assisted radiotherapy; nomogram; hormone inhibition |
| Journal Title: | Urology |
| Volume: | 70 |
| Issue: | 2 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2007-08-01 |
| Start Page: | 283 |
| End Page: | 287 |
| Language: | English |
| DOI: | 10.1016/j.urology.2007.03.060 |
| PUBMED: | 17826490 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 17 November 2011" - "CODEN: URGYA" - "Source: Scopus" |
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