The pathophysiology of murine retrovirus-induced leukemias Journal Article
| Authors: | Schiff, R. D.; Oliff, A. |
| Article Title: | The pathophysiology of murine retrovirus-induced leukemias |
| Abstract: | Murine leukemia viruses (MuLVs) are retroviruses which induce a broad spectrum of hematopoietic malignancies. In contrast to the acutely transforming retroviruses, MuLVs do not contain transduced cellular genes, or oncogenes. Nonetheless, MuLVs can cause leukemias quickly (4 to 6 weeks) and efficiently (up to 100% incidence) in susceptible strains of mice. The molecular basis of MuLV-induced leukemia is not clear. However, the contribution of individual viral genes to leukemogenesis can be assayed by creating novel viruses in vitro using recombinant DNA techniques. These genetically engineered viruses are tested in vivo for their ability to cause leukemia. Leukemogenic MuLVs possess genetic sequences which are not found in nonleukemogenic viruses. These sequences control the histologic type, incidence, and latency of disease induced by individual MuLVs. © 1986 CRC Press, Inc. |
| Keywords: | review; nonhuman; pathophysiology; dna replication; mouse; animal; mice; heredity; cell line; carcinogenesis; history; cloning, molecular; recombination, genetic; leukemogenesis; base sequence; dna, viral; tumor virus infections; virus replication; retrovirus; retroviridae; leukemia, erythroblastic, acute; murine leukemia virus; genes, viral; leukemia, experimental; friend murine leukemia virus; blood and hemopoietic system |
| Journal Title: | Critical Reviews in Oncology/Hematology |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 1040-8428 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1986-01-01 |
| Start Page: | 257 |
| End Page: | 323 |
| Language: | English |
| DOI: | 10.1016/s1040-8428(86)80041-5 |
| PUBMED: | 3527464 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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