Inhibition of sv40 dna replication by benzo[a]pyrene diol epoxide adducts: Two recovery modes Journal Article
| Authors: | Lockhart, M. L.; Ungers, G. E.; Deutsch, J. F.; Cavalieri, L. F.; Rosenberg, B. H. |
| Article Title: | Inhibition of sv40 dna replication by benzo[a]pyrene diol epoxide adducts: Two recovery modes |
| Abstract: | Anti-benzo[a]pyrene diol epoxide (BPDE) adducts produced in vitro in SV40 initially inhibit SV40 DNA replication in vivo, in cells unexposed to BPDE. A single adduct in a replicon is probably sufficient to block DNA replication. The recovery process appears to begin immediately after infection. The rate of recovery of replicative capacity is inversely related to the initial adduct number. Holding the infected cells temporarily under conditions that prevent viral DNA replication results subsequently in increased recovery, proportional to the holding time. The mechanism of recovery appears to be constitutive and prereplicative. In addition, there is a second mode of recovery which is induced by pretreatment of the host cells with BPDE before infection. The effect of pretreatment is similar to that of extending the holding time before replication: the first molecules begin to replicate earlier but the subsequent rate of recovery is unchanged. The induced mechanism may be either a limited stoichiometric repair process or a slow replicative bypass. © 1986 Elsevier Scientific Publishers Ireland Ltd. |
| Keywords: | nonhuman; dna replication; animals; dna repair; cell line; in vitro study; cercopithecus aethiops; kidney; cell culture; simian virus 40; dna, viral; dna adduct; virus replication; carcinogen; replicon; benzopyrenes; dihydroxybenzo[a]pyrene oxide; simiae; simian virus; priority journal; dna replication inhibition; carcinogen adducts; dna repair mechanisms; induced recovery |
| Journal Title: | Chemico-Biological Interactions |
| Volume: | 58 |
| ISSN: | 0009-2797 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 1986-01-01 |
| Start Page: | 217 |
| End Page: | 231 |
| Language: | English |
| DOI: | 10.1016/s0009-2797(86)80099-0 |
| PUBMED: | 3013438 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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