Pharmacokinetics of cis-diamminedichloroplatinum(II) after administration in hypertonic saline Journal Article

  


Authors: Bajorin, D. F.; Bosl, G. J.; Alcock, N. W.; Niedzwiecki, D.; Gallina, E.; Shurgot, B.
Article Title: Pharmacokinetics of cis-diamminedichloroplatinum(II) after administration in hypertonic saline
Abstract: Nephrotoxicity, the dose-limiting toxicity of cis-diamminedichloroplat-inum(II) (CDDP), is ameliorated when administered in hypertonic saline with normal saline hydration. To determine whether the diminished nephrotoxicity is associated with alteration of the pharmacokinetics of CDDP, we examined the pharmacokinetics of free and total platinum, platinum renal excretion, and urine electrolytes in patients given CDDF in hypertonic saline and in patients given CDDP in a conventional manner. The pharmacokinetics of free and total platinum for equal doses of CDDF were similar regardless of the vehicle of administration and the method of hydration. CDDP given in a vehicle of high chloride concentration with normal saline hydration resulted in a statistically significant increase in both urine volume and chloruresis compared to the conventional regimen. The decreased nephrotoxicity associated with administration of CDDP in hypertonic saline with saline diuresis may be related to increased chloruresis, urinary volume, or a combination of both, but did not appear to be related to an alteration in the pharmacokinetics. copyright. © 1986, American Association for Cancer Research. All rights reserved.
Keywords: adult; cancer chemotherapy; clinical article; aged; middle aged; cisplatin; nephrotoxicity; kidney; platinum; metabolic clearance rate; sodium chloride; therapy; intravenous drug administration; pharmacokinetics; intoxication; chlorides; diuresis; humans; human; priority journal; vehicles; saline solution, hypertonic
Journal Title: Cancer Research
Volume: 46
Issue: 11
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 1986-11-01
Start Page: 5969
End Page: 5972
Language: English
PUBMED: 3756934
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022978958&partnerID=40&md5=e3f0376ed59788e96d7e89ef99880a4d
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. Dean Bajorin
    658 Bajorin
  2. George Bosl
    430 Bosl
  3. Ellen J Gallina
    2 Gallina
  4. Donna Niedzwiecki
    61 Niedzwiecki
  5. Nancy Alcock
    23 Alcock
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