Intermittent endocrine therapy for advanced prostate cancer Journal Article
| Authors: | Klotz, L. H.; Herr, H. W.; Morse, M. J.; Whitmore, W. F. Jr |
| Article Title: | Intermittent endocrine therapy for advanced prostate cancer |
| Abstract: | Twenty patients with advanced prostate cancer have been treated with an intermittent endocrine therapy schedule. Hormone therapy (diethylstilbestrol in 19 patients and flutamide in 1 patient) was administered until a clinical response was clearly demonstrated and then it was withheld until symptoms recurred. Prior to treatment 17 of 20 patients had bone pain and positive radionuclide scans, two had asymptomatic pulmonary metastases, and one had symptomatic localized disease. Duration of endocrine therapy prior to withdrawal of all treatment ranged 2 to 70 months (median, 10 months). Disease progression occurred 1 to 24 months (median, 8 months) after interruption of therapy. All patients who relapsed had a rapid clinical response following resumption of endocrine therapy. Nine of ten patients rendered impotent by endocrine therapy resumed sexual activity within 3 months of stopping treatment. This data indicates that satisfactory palliation of advanced prostatic cancer can be achieved in selected patients using intermittent endocrine therapy. Copyright © 1986 American Cancer Society |
| Keywords: | clinical article; aged; bone neoplasms; drug efficacy; palliative care; lung neoplasms; bone pain; deep vein thrombosis; prostate cancer; prostatic neoplasms; pilot projects; bone; diethylstilbestrol; hormonal therapy; drug dose; flutamide; testosterone blood level; drug therapy; testosterone; adverse drug reaction; therapy; impotence; oral drug administration; endocrine system; middle age; drug intermittent therapy; male genital system; human; male; priority journal; peripheral vascular system |
| Journal Title: | Cancer |
| Volume: | 58 |
| Issue: | 11 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1986-12-01 |
| Start Page: | 2546 |
| End Page: | 2550 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19861201)58:11<2546::Aid-cncr2820581131>3.0.Co;2-n |
| PUBMED: | 2429759 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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