Trabecular (Merkel cell) carcinoma of the skin: Treatment of primary, recurrent, and metastatic disease Journal Article
| Authors: | Raaf, J. H.; Urmacher, C.; Knapper, W. K.; Shiu, M. H.; Cheng, E. W. K. |
| Article Title: | Trabecular (Merkel cell) carcinoma of the skin: Treatment of primary, recurrent, and metastatic disease |
| Abstract: | Four new patients with trabecular (Merkel cell) carcinoma of the skin are described, and an additional 76 patients from the literature are reviewed. The mean age of the combined group of patients was 68; 84% were 60 years or older. Primary tumors appeared most frequently on the head and neck (44%), leg (28%), arm (16%), or buttock (9%). No primary tumor appeared on the trunk. The rate of local recurrence was 36%, regional metastatic disease, 53%; distant metastases, 28%; and death due to metastatic tumor (minimally), 25%. It appears that trabecular carcinoma of the skin is more aggressive and lethal than previously thought. The authors recommend that patients with this tumor undergo wide resection of the primary site and, in healthy patients, prophylactic regional node dissection. Both radiation therapy and chemotherapy are effective in palliating unresectable disease. Copyright © 1986 American Cancer Society |
| Keywords: | aged; middle aged; prednisone; doxorubicin; fluorouracil; cancer combination chemotherapy; drug efficacy; chemotherapy; lymph node excision; adenocarcinoma; electron microscopy; metastasis; neoplasm recurrence, local; skin neoplasms; radiotherapy; skin cancer; cyclophosphamide; vincristine; histology; skin carcinoma; neoplasm metastasis; bleomycin; short survey; therapy; intravenous drug administration; streptozocin; merkel cell; trabecular carcinoma; humans; human; male; female; priority journal |
| Journal Title: | Cancer |
| Volume: | 57 |
| Issue: | 1 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1986-01-01 |
| Start Page: | 178 |
| End Page: | 182 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19860101)57:1<178::Aid-cncr2820570134>3.0.Co;2-t |
| PUBMED: | 3940617 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work