Adult ‘fetal‐like’ erythropoiesis characterizes recovery from bone marrow transplantation Journal Article
| Authors: | Weinberg, R. S.; Schofield, J. M.; Lenes, A. L.; Brochstein, J.; Alter, B. P. |
| Article Title: | Adult ‘fetal‐like’ erythropoiesis characterizes recovery from bone marrow transplantation |
| Abstract: | The transient fetal‐like erythropoiesis which appears during recovery from bone marrow transplantation has now been examined at the level of erythroid progenitor cells. A 7‐year‐old boy with β+‐thalassaemia major was studied during engraftment from his β‐thalassaemia trait sister. Hb F and i antigen rose as expected. Macrocytosis never developed, but red cell size distribution became very heterogeneous. Bone marrow CFU‐E and BFU‐E were detected by 30 d, prior to the appearance of reticulocytes. Marrow erythroid progenitor cell numbers were normal by 146 d, while those in the blood became normal by 360 d. After transplantation globin synthesis ratios in erythroid colonies were diagnostic of thalassaemia trait, indicating engraftment. Individual erythroid colonies derived from both blood and marrow at all times during reconstitution showed no correlation of Gγ and γ. Thus the fetal‐like stress erythropoiesis of marrow expansion following transplantation was derived from adult and not fetal progenitor cells. Copyright © 1986, Wiley Blackwell. All rights reserved |
| Keywords: | child; school child; human cell; cytology; bone marrow; erythroid precursor cell; erythropoiesis; stem cell; thalassemia; globin; beta thalassemia; hematopoietic stem cells; erythroblasts; bone marrow transplantation; colony-forming units assay; erythrocytes; human experiment; globins; colony forming unit; etiology; hemoglobin f; reticulocytes; humans; human; male; female; priority journal; article; burst forming unit; congenital disorder; blood and hemopoietic system |
| Journal Title: | British Journal of Haematology |
| Volume: | 63 |
| Issue: | 3 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1986-07-01 |
| Start Page: | 415 |
| End Page: | 424 |
| Language: | English |
| DOI: | 10.1111/j.1365-2141.1986.tb07518.x |
| PUBMED: | 3524655 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors wish to thank Dr Patricia Ciardina for referring the patient, and Dr Paul Berk for his help and support. |
