Loss of antibody titers and effectiveness of revaccination in post-chemotherapy pediatric sarcoma patients Journal Article
| Authors: | Yu, J.; Chou, A. J.; Lennox, A.; Kleiman, P.; Wexler, L. H.; Meyers, P. A.; Gorlick, R. |
| Article Title: | Loss of antibody titers and effectiveness of revaccination in post-chemotherapy pediatric sarcoma patients |
| Abstract: | Background. Little is known about the effects of chemotherapy on patient antibody titers to vaccine-preventable infectious diseases; thus, there is no standard protocol for revaccinating post-chemotherapy patients. Procedures. To assess losses of detectable antibody titers due to chemotherapy, we retrospectively examined antibody titers for tetanus, varicella, measles, mumps, rubella, hepatitis B, and polio in 109 pediatric sarcoma patients. We also evaluated revaccination data to determine current practices and efficacy of revaccination. We limited our sample to osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma patients to control for the chemotherapy regimen patients received. Results. Patients had pretreatment detectable antibody titer that fell within the range of healthy children's antibody titers. However, 71% of patients had post-chemotherapy negative titers for at least one infectious disease. Patients most commonly had negative titers for hepatitis B (64%). Few patients had negative titers for measles (14%), mumps (9%), rubella (4%), polio 1 (0%), polio 2 (2.9%), polio 3 (4.8%), tetanus (5%), or varicella (11%). Revaccinations most frequently administered were hepatitis B and polio. Conclusions. Our findings suggest that post-chemotherapy patients may need to be revaccinated against certain vaccine-preventable diseases including hepatitis B, tetanus, varicella, polio, measles, mumps, and rubella. Larger studies need to be performed to establish guidelines for revaccinating post-chemotherapy pediatric patients. © 2007 Wiley-Liss, Inc. |
| Keywords: | osteosarcoma; adolescent; adult; cancer chemotherapy; child; retrospective studies; major clinical study; hepatitis b; antineoplastic agents; chemotherapy; antineoplastic agent; practice guideline; drug effect; retrospective study; childhood cancer; ewing sarcoma; sarcoma; standard; vaccination; antibodies; infection prevention; rhabdomyosarcoma; antibody detection; hepatitis b vaccine; sarcoma, ewing's; antibody; chickenpox vaccine; chickenpox; infection complication; measles vaccine; tetanus toxoid; antibody titer; opportunistic infections; opportunistic infection; immunization; tetanus; poliomyelitis vaccine; measles; mumps; rubella; practice guidelines; revaccination; poliomyelitis; mumps vaccine; rubella vaccine; pediatric sarcoma |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 49 |
| Issue: | 5 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2007-10-15 |
| Start Page: | 656 |
| End Page: | 660 |
| Language: | English |
| DOI: | 10.1002/pbc.21277 |
| PUBMED: | 17554790 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: PBCEA" - "Source: Scopus" |
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