Acute herpetic and postherpetic neuralgia: Clinical review and current management Journal Article
| Authors: | Portenoy, R. K.; Duma, C.; Foley, K. M. |
| Article Title: | Acute herpetic and postherpetic neuralgia: Clinical review and current management |
| Abstract: | The pain of acute herpes zoster (HZ) may be severe, but it is usually transitory. A minority of patients, with the elderly at particular risk, go on to develop persistent, severe, often disabling pain called postherpetic neuralgia. Though the clinical features of these conditions are well known, the pathology of PHN is poorly described and the pathogenesis of the pain in both remains conjectural. During the past 60 years, an extraordinary number of pharmacological, anesthetic, and surgical therapies have been applied in an attempt to ameliorate the symptoms of acute herpes zoster, enhance its healing, prevent its transition to postherpetic neuralgia, and treat the pain of those with this complication. Relatively few treatments have been studied in a controlled manner, and fully reliable, safe, and effective therapeutic approaches for preventing and treating postherpetic neuralgia have not yet been found. This review summarizes current information on the epidemiology, clinical features, and pathology of herpes zoster and postherpetic neuralgia, and critically examines the accumulated experience with the various treatments. Guidelines for management are suggested. Copyright © 1986 American Neurological Association |
| Keywords: | adolescent; adult; child; aged; aged, 80 and over; child, preschool; prednisone; clinical feature; review; drug efficacy; nonhuman; treatment; herpes zoster; age factors; pathology; drug administration; epidemiology; drug therapy; immunosuppressive treatment; therapy; peripheral nervous system; acute disease; carbamazepine; oral drug administration; postherpetic neuralgia; neuralgia; etiology; middle age; amitriptyline; varicella zoster virus; topical drug administration; subcutaneous drug administration; human; priority journal; support, u.s. gov't, p.h.s. |
| Journal Title: | Annals of Neurology |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 0364-5134 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1986-12-01 |
| Start Page: | 651 |
| End Page: | 664 |
| Language: | English |
| DOI: | 10.1002/ana.410200602 |
| PUBMED: | 3545049 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: We thank Dr Richard Price for his review of the manuscript. |
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