Recurrent ependymoma treated with high-dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary-ovarian axis Journal Article


Authors: Yoffe, R.; Khakoo, Y.; Dunkel, I. J.; Souweidane, M.; Lis, E.; Sklar, C.
Article Title: Recurrent ependymoma treated with high-dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary-ovarian axis
Abstract: Due to high rates of recurrence, the prognosis of childhood ependymoma remains guarded. Anecdotal evidence suggests that tamoxifen may have a role in the treatment of these tumors. We present a case of a child with recurrent ependymoma treated with tamoxifen who showed tumor regression on two separate occasions. However, treatment with tamoxifen resulted in the development of large ovarian cysts associated with supraphysiological plasma concentrations of estradiol. © 2005 Wiley-Liss, Inc.
Keywords: child; school child; unclassified drug; clinical feature; case report; cisplatin; cancer combination chemotherapy; drug withdrawal; side effect; drug megadose; nuclear magnetic resonance imaging; brain tumor; follow up; multiple cycle treatment; tumor volume; etoposide; recurrence; cyclophosphamide; vincristine; drug effect; gonadorelin; puberty; leuprorelin; cancer regression; blood; tumor burden; chemically induced disorder; echography; tamoxifen; recurrent disease; ependymoma; gonadorelin agonist; estradiol; follitropin; hormone determination; ovary cyst; sexual maturation; estradiol blood level; luteinizing hormone; gnrh agonist; ovarian cysts; depot lupron; gonadorelin test; hypophysis gonad system
Journal Title: Pediatric Blood and Cancer
Volume: 49
Issue: 5
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2007-10-15
Start Page: 758
End Page: 760
Language: English
DOI: 10.1002/pbc.20647
PUBMED: 16261561
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: PBCEA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Ira J Dunkel
    255 Dunkel
  2. Charles A Sklar
    276 Sklar
  3. Eric Lis
    103 Lis
  4. Yasmin Khakoo
    100 Khakoo