Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer Journal Article
| Authors: | Shike, M.; Gillin, J. S.; Kemeny, N.; Daly, J. M.; Kurtz, R. C. |
| Article Title: | Severe gastroduodenal ulcerations complicating hepatic artery infusion chemotherapy for metastatic colon cancer |
| Abstract: | Patients receiving continuous hepatic artery infusion chemotherapy (HAIC) with 5‐fluoro‐2′‐deoxyuridine for colorectal carcinoma metastatic to the liver frequently complain of nonspecific abdominal discomfort. To determine the etiology of these symptoms we performed upper gastrointestinal endoscopy on symptomatic patients during the course of HAIC. Among 40 patients receiving HAIC of 5‐fluoro‐2′‐deoxyuridine, 21 (53%) developed epigastric pain. They all had upper gastrointestinal endoscopy and 19 were found to have gastroduodenal ulcerations and or erosions. In two patients the infusion catheter eroded into the duodenum. The pathogenesis of the mucosal disease is not clear, but because symptoms responded to discontinuation of HAIC but not to therapy with cimetidine, a direct toxic effect of chemotherapy is postulated. We conclude that patients who complain of upper gastrointestinal symptoms while receiving continuous HAIC with 5‐fluoro‐2′‐deoxyuridine should be investigated for the development of gastroduodenal ulcerations and erosions and that chemotherapy should be withheld if such lesions are found. Copyright © 1986, Wiley Blackwell. All rights reserved |
| Keywords: | adult; cancer chemotherapy; clinical article; aged; middle aged; liver neoplasms; colorectal cancer; colonic neoplasms; colorectal carcinoma; gastrointestinal toxicity; liver metastasis; liver; drug therapy, combination; colon cancer; stomach ulcer; diagnosis; intraarterial drug administration; regional perfusion; infusions, intra-arterial; radioisotope; drug therapy; macrosalb tc 99m; floxuridine; small intestine; gastroscopy; adverse drug reaction; therapy; infusion; hepatic artery; stomach; acute disease; duodenum ulcer; cimetidine; technetium sulfur colloid tc 99m; duodenal ulcer; intoxication; antacid agent; large intestine; stomach pain; humans; human; male; female; priority journal; peripheral vascular system; duodenum erosion; stomach erosion |
| Journal Title: | American Journal of Gastroenterology |
| Volume: | 81 |
| Issue: | 3 |
| ISSN: | 0002-9270 |
| Publisher: | Wolters Kluwer Health |
| Date Published: | 1986-03-01 |
| Start Page: | 176 |
| End Page: | 179 |
| Language: | English |
| DOI: | 10.1111/j.1572-0241.1986.tb01454.x |
| PUBMED: | 2937289 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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