Management of coexisting Hodgkin's disease and pregnancy Journal Article


Authors: Nisce, L. Z.; Tome, M. A.; He, S.; Lee, B. J. 3rd; Kutcher, G. J.
Article Title: Management of coexisting Hodgkin's disease and pregnancy
Abstract: The management of pregnant women with active Hodgkin's disease (H.D.) should be individualized depending on the stage, the presence of infradiaphragmatic involvement, and age of gestation. Seventeen women aged 16-31 years with coexisting H.D. and pregnancy were followed between 1969 and 1982. H.D. was diagnosed during pregnancy in 15 patients and two became pregnant while on treatment. Seven women whose pregnancies were allowed to proceed uninterrupted were irradiated to supradiaphragmatic sites to doses of 1,500-2,000 rad during the second or third trimester; all had full term spontaneous normal deliveries and normal infants. Fetal doses ranged from 2-50 rad. Two patients treated with Vinblastine throughout three pregnancies delivered normal full term infants. Pregnancy was interrupted in six patients at 6-20 weeks of gestation for various reasons. In spite of several months delay in initiation of definitive therapy, the outcome of H.D. was not adversely affected in the majority of uninterrupted pregnancies as evidenced by long term disease-free survivals of 6-11 years in four of seven patients who were irradiated; the children now aged 6-11 years are also alive and reported normal.
Keywords: cancer chemotherapy; clinical article; prednisone; cancer radiotherapy; chemotherapy; radiotherapy; vincristine; chlormethine; procarbazine; thiotepa; hodgkin disease; lymphatic system; pregnancy; fetus; radioisotope; drug therapy; vinblastine sulfate; cobalt 60; therapy; intravenous drug administration; human; priority journal; blood and hemopoietic system
Journal Title: American Journal of Clinical Oncology
Volume: 9
Issue: 2
ISSN: 0277-3732
Publisher: Lippincott Williams & Wilkins  
Date Published: 1986-04-01
Start Page: 146
End Page: 151
Language: English
DOI: 10.1097/00000421-198604000-00009
PROVIDER: scopus
PUBMED: 3717081
DOI/URL:
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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  1. Gerald J Kutcher
    106 Kutcher