Benzydamine HCl, a new agent for the treatment of radiation mucositis of the oropharynx Journal Article
| Authors: | Kim, J. H.; Chu, F. C. H.; Lakshmi, V.; Houde, R. |
| Article Title: | Benzydamine HCl, a new agent for the treatment of radiation mucositis of the oropharynx |
| Abstract: | Benzydamine HCl is a new nonsteroidal analgesic and antiinflammatory compound which is not chemically related to local anesthetics such as procaine and xylocaine. A double-blind, randomized clinical investigation was carried out to determine the analgesic and anti-inflammatory effectiveness of benzydamine HCl in patients with radiation-induced mucositis of the oropharynx. Of the 67 patients in the study, 37 were on benzydamine and 30 on placebo. Patients developed radiation mucositis, hyperemia, and throat pain when the total radiation dose reached above 2,000 rad over 2 weeks (200 rad per fraction, five treatments per week). Analysis of the data showed that benzydamine HCl used as a rinse/gargle provided a statistically significant and clinically meaningful alleviation of the symptoms of oropharyngeal mucositis. There was also significant improvement in terms of reduction in hyperemia and mucositis in benzydamine group. No systemic side effects associated with benzydamine medication were noted. In view of the relative ineffectiveness of systemic analgesics and topical anesthetics for these conditions, benzydamine HCl promises to be a useful addition to the therapeutic armamentarium. |
| Keywords: | clinical article; controlled study; placebo; mucosa inflammation; radiotherapy; radiation injury; drug therapy; mouth; therapy; oropharynx; pharynx; prevention; topical drug administration; human; priority journal; benzydamine |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1986-04-01 |
| Start Page: | 132 |
| End Page: | 134 |
| Language: | English |
| DOI: | 10.1097/00000421-198604000-00006 |
| PUBMED: | 3521255 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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