Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas Journal Article


Authors: Yeh, J. J.; Gonen, M.; Tomlinson, J. S.; Idrees, K.; Brennan, M. F.; Fong, Y.
Article Title: Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas
Abstract: Background: Blood transfusion is thought to have an immunosuppressive effect. The aims of this study were to examine survival in patients with pancreatic cancer receiving blood transfusion in association with pancreaticoduodenectomy, and to define preoperative risk factors for subsequent transfusion. Methods: A retrospective review was performed of a prospective database of patients with exocrine tumours of the head of the pancreas who had undergone pancreaticoduodenectomy between 1998 and 2003. Clinical data, transfusion records and preoperative laboratory values were recorded. Results: A total of 294 patients underwent pancreaticoduodenectomy for exocrine tumours in the pancreatic head. Of these, 140 (47.6 per cent) received a blood transfusion. Their median survival was 18 months, compared with 24 months for those who did not have a transfusion (P = 0.036). Postoperative transfusion, margin status and node stage were independent predictors of survival. Age and preoperative total bilirubin and haemoglobin levels were the only preoperative factors that correlated with transfusion. Conclusion: In patients with exocrine tumours of the pancreas, blood transfusion should be avoided when possible. Preoperative risk factors can identify patients who are likely to require transfusion and would therefore benefit most from blood conservation methods. Copyright © 2007 British Journal of Surgery Society Ltd.
Keywords: adult; cancer survival; controlled study; treatment outcome; aged; aged, 80 and over; middle aged; survival rate; retrospective studies; major clinical study; review; pancreas cancer; preoperative care; pancreatic neoplasms; pancreaticoduodenectomy; risk factors; risk factor; risk assessment; postoperative complication; postoperative complications; bilirubin; pancreas tumor; blood transfusion; multivariate analysis; immunosuppressive treatment; erythrocyte transfusion; hemoglobins; blood loss, surgical; peroperative care
Journal Title: British Journal of Surgery
Volume: 94
Issue: 4
ISSN: 0007-1323
Publisher: Oxford University Press  
Date Published: 2007-04-01
Start Page: 466
End Page: 472
Language: English
DOI: 10.1002/bjs.5488
PUBMED: 17330243
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "CODEN: BJSUA" - "Source: Scopus"
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Jenjen Yeh
    9 Yeh
  2. Kamran Idrees
    10 Idrees
  3. Murray F Brennan
    1059 Brennan
  4. Mithat Gonen
    1030 Gonen
  5. Yuman Fong
    775 Fong