Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas Journal Article
| Authors: | Yeh, J. J.; Gonen, M.; Tomlinson, J. S.; Idrees, K.; Brennan, M. F.; Fong, Y. |
| Article Title: | Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas |
| Abstract: | Background: Blood transfusion is thought to have an immunosuppressive effect. The aims of this study were to examine survival in patients with pancreatic cancer receiving blood transfusion in association with pancreaticoduodenectomy, and to define preoperative risk factors for subsequent transfusion. Methods: A retrospective review was performed of a prospective database of patients with exocrine tumours of the head of the pancreas who had undergone pancreaticoduodenectomy between 1998 and 2003. Clinical data, transfusion records and preoperative laboratory values were recorded. Results: A total of 294 patients underwent pancreaticoduodenectomy for exocrine tumours in the pancreatic head. Of these, 140 (47.6 per cent) received a blood transfusion. Their median survival was 18 months, compared with 24 months for those who did not have a transfusion (P = 0.036). Postoperative transfusion, margin status and node stage were independent predictors of survival. Age and preoperative total bilirubin and haemoglobin levels were the only preoperative factors that correlated with transfusion. Conclusion: In patients with exocrine tumours of the pancreas, blood transfusion should be avoided when possible. Preoperative risk factors can identify patients who are likely to require transfusion and would therefore benefit most from blood conservation methods. Copyright © 2007 British Journal of Surgery Society Ltd. |
| Keywords: | adult; cancer survival; controlled study; treatment outcome; aged; aged, 80 and over; middle aged; survival rate; retrospective studies; major clinical study; review; pancreas cancer; preoperative care; pancreatic neoplasms; pancreaticoduodenectomy; risk factors; risk factor; risk assessment; postoperative complication; postoperative complications; bilirubin; pancreas tumor; blood transfusion; multivariate analysis; immunosuppressive treatment; erythrocyte transfusion; hemoglobins; blood loss, surgical; peroperative care |
| Journal Title: | British Journal of Surgery |
| Volume: | 94 |
| Issue: | 4 |
| ISSN: | 0007-1323 |
| Publisher: | Oxford University Press |
| Date Published: | 2007-04-01 |
| Start Page: | 466 |
| End Page: | 472 |
| Language: | English |
| DOI: | 10.1002/bjs.5488 |
| PUBMED: | 17330243 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "CODEN: BJSUA" - "Source: Scopus" |
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