Colorectal cancer screening Journal Article
| Author: | Winawer, S. J. |
| Article Title: | Colorectal cancer screening |
| Abstract: | Colorectal cancer is a worldwide problem having global increases in the number of cases and deaths because of the expanding and aging of the population in both developing and developed countries. Screening methods are available which can reduce the incidence by removal of adenomas and can reduce deaths in diagnosed cancer cases by earlier stage detection. Faecal occult blood testing has the strongest proof of effectiveness based on randomised control trials; sigmoidoscopy has lesser proof based on case control studies, and barium enema the weakest proof of effectiveness. Screening colonoscopy has not been subjected to a randomised trial but there is now considerable evidence of its performance and safety and it has the ability to screen, diagnose, and treat (polypectomy) in one test and it is becoming increasingly offered. Many guidelines are now in place, all with positive a position on the effectiveness of screening. However, screening rates are low and many barriers are present that need to be overcome in order to make a major global impact on colorectal cancer incidence and mortality. © 2007. |
| Keywords: | case control study; genetics; clinical trial; disease course; mortality; review; cancer risk; patient selection; pathophysiology; cancer staging; methodology; cancer incidence; colorectal cancer; genetic predisposition to disease; incidence; risk factors; cancer screening; mass screening; practice guideline; risk factor; cancer mortality; pedigree; colorectal neoplasms; cost effectiveness analysis; economics; diagnostic agent; screening; disease progression; colonoscopy; colorectal adenoma; colorectal tumor; developed country; practice guidelines as topic; prediction and forecasting; predictive value of tests; contrast medium; contrast media; aging; familial cancer; safety; developing country; high risk population; genetic risk; genetic predisposition; genetic screening; gastrointestinal endoscopy; polypectomy; cost-benefit analysis; sigmoidoscopy; cowden syndrome; polyps; cost benefit analysis; occult blood; computed tomographic colonography; colonography, computed tomographic; barium enema; juvenile polyp; familial colon polyposis; peutz jeghers syndrome; adenomas; colon polyposis; ctc; stool dna; barium derivative; barium compounds |
| Journal Title: | Best Practice & Research: Clinical Gastroenterology |
| Volume: | 21 |
| Issue: | 6 |
| ISSN: | 1521-6918 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2007-12-01 |
| Start Page: | 1031 |
| End Page: | 1048 |
| Language: | English |
| DOI: | 10.1016/j.bpg.2007.09.004 |
| PUBMED: | 18070702 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 17 November 2011" - "CODEN: BPRCB" - "Source: Scopus" |
