Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70 Journal Article
| Authors: | Weinstock, D. M.; Brunet, E.; Jasin, M. |
| Article Title: | Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70 |
| Abstract: | Chromosomal translocations in lymphoid tumours can involve antigen-receptor loci undergoing V(D)J recombination. Here, we show that translocations are recovered from the joining of RAG-generated double-strand breaks (DSbs) on one chromosome to an endonuclease-generated DSb on a second chromosome, providing evidence for the participation of non-raG DSbs in some lymphoid translocations. Surprisingly, translocations are increased in cells deficient for the nonhomologous end-joining (nHeJ) protein Ku70, implicating non-canonical joining pathways in their etiology. |
| Keywords: | controlled study; dna-binding proteins; nonhuman; animal cell; mouse; animals; mice; homeodomain proteins; carcinogenesis; dna strand breakage; fluorescence in situ hybridization; genetic recombination; recombination, genetic; reporter gene; dna breaks, double-stranded; base sequence; embryonic stem cells; translocation, genetic; genes, reporter; sequence homology, nucleic acid; endonuclease; ku antigen; rag1 protein; rag2 protein; chromosome 17; reciprocal chromosome translocation; antigens, nuclear; chromosome 14; lymphatic system tumor |
| Journal Title: | Nature Cell Biology |
| Volume: | 9 |
| Issue: | 8 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-08-01 |
| Start Page: | 978 |
| End Page: | 981 |
| Language: | English |
| DOI: | 10.1038/ncb1623 |
| PUBMED: | 17643113 |
| PROVIDER: | scopus |
| PMCID: | PMC3065497 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 33" - "Export Date: 17 November 2011" - "CODEN: NCBIF" - "Source: Scopus" |
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