Investigational therapies for metastatic thyroid carcinoma Journal Article
| Authors: | Tuttle, R. M.; Leboeuf, R. |
| Article Title: | Investigational therapies for metastatic thyroid carcinoma |
| Abstract: | Although traditional chemotherapy has yielded disappointing results in the therapy of progressive metastatic thyroid cancer, the recent development of a wide range of novel therapies targeting critical steps in the pathogenesis of thyroid cancer has led to a renewed interest in thyroid cancer clinical trials. This review provides an overview of the pathogenesis of thyroid cancer with particular emphasis on specific molecular targets that can be modulated with these novel agents. The article reviews the results for the small number of thyroid cancer patients included in published therapeutic trials and critically examines patient selection criteria for inclusion in clinical trials. Given the dramatic increase in availability of thyroid cancer clinical trials, all patients with radioactive iodine-refractory, progressive metastatic thyroid cancer should be considered for inclusion in a novel therapy trial. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | signal transduction; vasculotropin; gene mutation; thalidomide; review; carcinoma, squamous cell; sorafenib; angiogenesis inhibitor; bevacizumab; sunitinib; patient selection; antineoplastic agents; unindexed drug; metastasis; bortezomib; mitogen activated protein kinase inhibitor; epidermal growth factor receptor; carcinoma, papillary; antineoplastic activity; cetuximab; tyrosine kinase inhibitors; monoclonal antibody; epigenetics; celecoxib; mammalian target of rapamycin; gefitinib; combretastatin a4; vandetanib; vatalanib; vorinostat; 5 aza 2' deoxycytidine; thyroid cancer; thyroid carcinoma; thyroid neoplasms; isotretinoin; trastuzumab; rosiglitazone; b raf kinase; rapamycin; clinical trials; azacitidine; valproic acid; scatter factor receptor; carcinoma, medullary; geldanamycin; cancer gene therapy; 2 (2 amino 3 methoxyphenyl)chromone; novel therapy; therapies, investigational |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 5 |
| Issue: | 6 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2007-07-01 |
| Start Page: | 641 |
| End Page: | 646 |
| Language: | English |
| PUBMED: | 17623615 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "Source: Scopus" |
