Differentiation of nonconventional "carbanions" - The total synthesis of nemorosone and clusianone Journal Article
| Authors: | Tsukano, C.; Siegel, D. R.; Danishefsky, S. J. |
| Article Title: | Differentiation of nonconventional "carbanions" - The total synthesis of nemorosone and clusianone |
| Abstract: | (Chemical Equation Presented) An unconventional approach: The total syntheses of nemorosone (1) and clusianone (2) have been achieved in a direct fashion through the generation and exploitation of nonconventional anions arising from a common intermediate (3, see scheme). The key skeleton-building stages are allylative de-aromatization and iodinative cyclization. These acylphloroglucinol natural products display promising cytotoxic and anti-HIV activity, respectively. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | unclassified drug; cytotoxicity; chemical structure; molecular structure; cyclization; synthesis; total synthesis; synthesis (chemical); natural products; bicyclo compound; drug products; nemorosone; clusianone; carbanions; negative ions; benzophenone derivative; benzophenones; bicyclo compounds |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 46 |
| Issue: | 46 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2007-01-01 |
| Start Page: | 8840 |
| End Page: | 8844 |
| Language: | English |
| DOI: | 10.1002/anie.200703886 |
| PUBMED: | 17935090 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 17 November 2011" - "CODEN: ACIEA" - "Source: Scopus" |
