The Sickness Behavior Inventory-Revised: Sickness behavior and its associations with depression and inflammation in patients with metastatic lung cancer Journal Article
| Authors: | McFarland, D. C.; Walsh, L. E.; Saracino, R.; Nelson, C. J.; Breitbart, W.; Rosenfeld, B. |
| Article Title: | The Sickness Behavior Inventory-Revised: Sickness behavior and its associations with depression and inflammation in patients with metastatic lung cancer |
| Abstract: | Background Inflammation may contribute to the high prevalence of depressive symptoms seen in lung cancer. Sickness behavior is a cluster of symptoms induced by inflammation that are similar but distinct from depressive symptoms. The Sickness Behavior Inventory-Revised (SBI-R) was developed to measure sickness behavior. We hypothesized that the SBI-R would demonstrate adequate psychometric properties in association with inflammation. Method Participants with stage IV lung cancer (n = 92) were evaluated for sickness behavior using the SBI-R. Concomitant assessments were made of depression (Patient Hospital Questionniare-9, Hospital Anxiety and Depression Scale) and inflammation [C-reactive protein (CRP)]. Classical test theory (CTT) was applied and multivariate models were created to explain SBI-R associations with depression and inflammation. Factor Analysis was also used to identify the underlying factor structure of the hypothesized construct of sickness behavior. A longitudinal analysis was conducted for a subset of participants. Results The sample mean for the 12-item SBI-R was 8.3 (6.7) with a range from 0 to 33. The SBI-R demonstrated adequate internal consistency with a Cronbach's coefficient of 0.85, which did not increase by more than 0.01 with any single-item removal. This analysis examined factor loadings onto a single factor extracted using the principle components method. Eleven items had factor loadings that exceeded 0.40. SBI-R total scores were significantly correlated with depressive symptoms (r = 0.78, p < 0.001) and CRP (r = 0.47, p < 0.001). Multivariate analyses revealed that inflammation and depressive symptoms explained 67% of SBI-R variance. Significance of results The SBI-R demonstrated adequate reliability and construct validity in this patient population with metastatic lung cancer. The observed findings suggest that the SBI-R can meaningfully capture the presence of sickness behavior and may facilitate a greater understanding of inflammatory depression. Copyright © The Author(s), 2020. Published by Cambridge University Press. |
| Keywords: | inflammation; lung cancer; c-reactive protein; depression; sickness behavior inventory |
| Journal Title: | Palliative and Supportive Care |
| Volume: | 19 |
| Issue: | 3 |
| ISSN: | 1478-9515 |
| Publisher: | Cambridge University Press |
| Date Published: | 2021-06-01 |
| Start Page: | 312 |
| End Page: | 321 |
| Language: | English |
| DOI: | 10.1017/s1478951520001169 |
| PROVIDER: | scopus |
| PMCID: | PMC8311665 |
| PUBMED: | 33222717 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2021 -- Source: Scopus |
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