Contemporary management of actinic keratosis Editorial
| Authors: | Navarrete-Dechent, C.; Marghoob, A. A.; Marchetti, M. A. |
| Title: | Contemporary management of actinic keratosis |
| Abstract: | Actinic keratosis (AK) is a skin lesion characterized by itraepithelial keratinocyte dysplasia and molecular alterations shared with normal chronically sun-damaged skin and squamous cell carcinoma (SCC). AK can undergo spontaneous regression, stable existence, or malignant transformation to cutaneous SCC with progression rates to SCC ranging from 0% to 0.5% per lesion-year and AK spontaneous regression of 15–63%. As AK is a potential precursor of invasive SCC, it is commonly treated to mitigate the risk of malignant progression, including metastasis and death. There is a myriad of available spots (e.g. cryotherapy) and field (e.g. 5-fluorouracil, imiquimod photodynamic therapy) treatments for AK. Recently published randomized clinical trials have helped bridge the gap on AK management. In this viewpoint, we sought to summarize the most up-to-date evidence in the management of AK. © 2019 Taylor & Francis Group, LLC. |
| Keywords: | squamous cell carcinoma; treatment; actinic keratosis; randomized controlled trial; skin cancer; non-melanoma skin cancer; evidence; keratinocyte carcinoma; number needed to treat |
| Journal Title: | Journal of Dermatological Treatment |
| Volume: | 32 |
| Issue: | 5 |
| ISSN: | 0954-6634 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2021-01-01 |
| Start Page: | 572 |
| End Page: | 574 |
| Language: | English |
| DOI: | 10.1080/09546634.2019.1682504 |
| PUBMED: | 31621454 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2021 -- Source: Scopus |
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