Clofarabine induced durable complete remission in heavily pretreated adolescents with relapsed and refractory leukemia Journal Article


Authors: Steinherz, P. G.; Meyers, P. A.; Steinherz, L. J.; Jeha, S.
Article Title: Clofarabine induced durable complete remission in heavily pretreated adolescents with relapsed and refractory leukemia
Abstract: Current treatments for relapsed/refractory leukemias are unable to achieve extended remissions in most patients even with multiagent chemotherapy. Clofarabine is a new nucleoside analog that has demonstrated clinical benefit in phase I-II studies, and is currently being studied in children and adults with leukemias and has been approved for the treatment of children with relapsed or refractory acute lymphocytic leukemia. We report the experience of three adolescents, two with acute lymphocytic leukemia in 3rd relapse and one with relapsed/refractory acute myeloid leukemia, who achieved complete remission with clofarabine. The remissions were sustained with repeated cycles of monotherapy for 47, 59, and 64 weeks, respectively. © 2007 Lippincott Williams & Wilkins, Inc.
Keywords: adolescent; adult; treatment outcome; antibiotic agent; acute granulocytic leukemia; busulfan; fludarabine; prednisone; clinical feature; clinical trial; case report; cancer combination chemotherapy; drug dose reduction; cancer radiotherapy; cytarabine; methotrexate; drug megadose; nuclear magnetic resonance imaging; follow up; multiple cycle treatment; bone marrow suppression; etoposide; blood toxicity; recurrence; cyclophosphamide; dexamethasone; melphalan; vincristine; stem cell transplantation; thiotepa; febrile neutropenia; chemotherapy induced emesis; drug induced headache; bone marrow biopsy; leukemia, myeloid; daunorubicin; graft versus host reaction; remission induction; asparaginase; acute lymphocytic leukemia; leukemia relapse; clofarabine; tioguanine; acute disease; magnetic resonance angiography; low molecular weight heparin; mercaptopurine; leukemia remission; aml; complete remission; adenine nucleotides; arabinonucleosides; all; colony stimulating factor; leukemia, lymphocytic, acute; multiply relapsed all; multiply relapsed aml; purine nucleoside analog; refractory leukemia
Journal Title: Journal of Pediatric Hematology/Oncology
Volume: 29
Issue: 9
ISSN: 1077-4114
Publisher: Lippincott Williams & Wilkins  
Date Published: 2007-09-01
Start Page: 656
End Page: 658
Language: English
DOI: 10.1097/MPH.0b013e318142b94b
PUBMED: 17805046
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: JPHOF" - "Source: Scopus"
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MSK Authors
  1. Peter G Steinherz
    179 Steinherz
  2. Paul Meyers
    260 Meyers