Concordance between 21-gene recurrence scores in multifocal or multicentric breast carcinomas differs by age and histologic subtype Journal Article
| Authors: | Pawloski, K. R.; Wen, H. Y.; Tadros, A. B.; Abbate, K.; Morrow, M.; El-Tamer, M. |
| Article Title: | Concordance between 21-gene recurrence scores in multifocal or multicentric breast carcinomas differs by age and histologic subtype |
| Abstract: | Background: Among patients with multifocal or multicentric (MF/MC) breast cancer (BC) of similar morphology, concordance in Oncotype DX recurrence scores (RS) between tumors has been reported to be 87%. The effect of age and variation in histologic subtypes on RS concordance according to TAILORx criteria is unknown. Methods: We identified patients with MF/MC, estrogen receptor-positive, HER2-negative, node-negative BC with two or more RS results treated at our institution from 2009 to 2018. Patients were analyzed by age group (≤ 50 and > 50 years). Low- and high-risk cut-offs were RS ≤ 25 and > 25 for age > 50 years, and RS ≤ 20 and > 20 for age ≤ 50 years. RS concordance was defined as no change in management based on RS variation between lesions. Results: Overall, 120 patients with MF/MC BC were identified—82 (68.3%) aged > 50 years and 38 (31.7%) aged ≤ 50 years. Patients aged ≤ 50 years had higher mean RS for both multifocal (20 vs. 14; p = 0.006) and multicentric (17 vs. 13; p = 0.003) tumors and more frequently had high-risk tumors (p < 0.0001). Among patients aged > 50 years, 95.1% had RS concordance between tumors (same subtype, 98.2%; variable subtype, 88.9%; p = 0.1). Among patients aged ≤ 50 years, RS concordance was 81.6%. Conclusions: Among patients with MF/MC BC, RS concordance was high, particularly in those aged > 50 years with tumors of the same histologic subtype. RS testing of one focus may be sufficiently prognostic and predictive in patients aged > 50 years, regardless of subtype concordance. Testing of individual foci should be considered in patients aged ≤ 50 years due to a higher likelihood of RS discordance. © 2021, Society of Surgical Oncology. |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 28 |
| Issue: | 8 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2021-08-01 |
| Start Page: | 4256 |
| End Page: | 4262 |
| Language: | English |
| DOI: | 10.1245/s10434-020-09429-y |
| PUBMED: | 33393037 |
| PROVIDER: | scopus |
| PMCID: | PMC8253864 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2021 -- Source: Scopus |
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