Diet-regulated production of PDGFcc by macrophages controls energy storage Journal Article
| Authors: | Cox, N.; Crozet, L.; Holtman, I. R.; Loyher, P. L.; Lazarov, T.; White, J. B.; Mass, E.; Stanley, E. R.; Elemento, O.; Glass, C. K.; Geissmann, F. |
| Article Title: | Diet-regulated production of PDGFcc by macrophages controls energy storage |
| Abstract: | The mechanisms by which macrophages regulate energy storage remain poorly understood. We identify in a genetic screen a platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF)-family ortholog, Pvf3, that is produced by macrophages and is required for lipid storage in fat-body cells of Drosophila larvae. Genetic and pharmacological experiments indicate that the mouse Pvf3 ortholog PDGFcc, produced by adipose tissue-resident macrophages, controls lipid storage in adipocytes in a leptin receptor- and C-C chemokine receptor type 2-independent manner. PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon PDGFcc blockade, excess lipids are redirected toward thermogenesis in brown fat. These data identify a macrophage-dependent mechanism, conducive to the design of pharmacological interventions, that controls energy storage in metazoans. © 2021 American Association for the Advancement of Science. All rights reserved. |
| Keywords: | platelet derived growth factor; vasculotropin; adult; controlled study; unclassified drug; nonhuman; animal cell; mouse; animal tissue; lipid; animal experiment; drosophila; protein synthesis; newborn; paracrine signaling; dietary intake; macrophage; genetic screening; energy metabolism; chemokine receptor ccr2; adipose tissue; metazoa; experimental study; leptin receptor; adipocyte; brown adipose tissue; lipid storage; energy storage; thermogenesis; pharmacological parameters; larval stage; cell component; male; female; article; fat pad; protein platelet derived growth factor cc; artificial diet; biological production |
| Journal Title: | Science |
| Volume: | 373 |
| Issue: | 6550 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2021-07-02 |
| Start Page: | eabe9383 |
| Language: | English |
| DOI: | 10.1126/science.abe9383 |
| PUBMED: | 34210853 |
| PROVIDER: | scopus |
| PMCID: | PMC9558257 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2021 -- Source: Scopus |
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