Chemodynamic nanomaterials for cancer theranostics Review


Authors: Xin, J.; Deng, C.; Aras, O.; Zhou, M.; Wu, C.; An, F.
Review Title: Chemodynamic nanomaterials for cancer theranostics
Abstract: It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.
Keywords: hypoxia; combination therapy; theranostics; chemodynamic therapy; fenton reaction
Journal Title: Journal of Nanobiotechnology
Volume: 19
ISSN: 1477-3155
Publisher: Biomed Central Ltd  
Date Published: 2021-06-28
Start Page: 192
Language: English
DOI: 10.1186/s12951-021-00936-y
PUBMED: 34183023
PROVIDER: scopus
PMCID: PMC8240398
DOI/URL:
Notes: Review -- Export Date: 2 August 2021 -- Source: Scopus
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  1. Omer Aras
    77 Aras